The linear amplification of chemically sequenced DNA with DNA polymerase from Thermus aquatlcus permits the direct detection of DNA methylation and protein–DNA interaction sites in vivo.
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Saluz, H., Jost, J. Genomic footprinting with Taq polymerase. Nature 338, 277 (1989). https://doi.org/10.1038/338277a0
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DOI: https://doi.org/10.1038/338277a0