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DNA-protein conjugates can enter mitochondria via the protein import pathway

Nature volume 338, pages 170–172 (1989)Cite this article

Abstract

MITOCHONDRIA import most of their proteins and small molecules from the cytoplasm1. There is some tentative evidence that they import some of their RNAs1–4, but it is not known how nucleic acids could enter mitochondria. Here, we show that isolated yeast mitochondria can import a single-stranded or double-stranded 24-base pair piece of DNA whose 5' end is covalently linked to the C-terminus of a mitochondrial precursor protein.

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Affiliations

  1. Department of Biochemistry, Biozentrum, University of Basel, CH-4056, Basel, Switzerland

    Dietmar Vestweber & Gottfried Schatz

Authors
  1. Dietmar Vestweber
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  2. Gottfried Schatz
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Vestweber, D., Schatz, G. DNA-protein conjugates can enter mitochondria via the protein import pathway. Nature 338, 170–172 (1989). https://doi.org/10.1038/338170a0

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  • DOI: https://doi.org/10.1038/338170a0

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