Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Designing CD4 immunoadhesins for AIDS therapy

Nature volume 337, pages 525–531 (1989)Cite this article

Abstract

A newly-constructed antibody-like molecule containing the gp!20-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma half-life, other antibody-like properties, and potential to block all HIV isolates, make it a good candidate for therapeutic use.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Curran, J. et al. Science 239, 610–616 (1988).

    Article  ADS  CAS  Google Scholar 

  2. Hu, S.-L. et al. Nature 328, 721–723 (1987).

    Article  ADS  CAS  Google Scholar 

  3. Berman, P. et al. Proc. natn. Acad. Sci. U.S.A. 85, 5200–5204 (1988).

    Article  ADS  CAS  Google Scholar 

  4. Prince, A. et al. Proc. natn. Acad. Sci. U.S.A. 85, 6944–6948 (1988).

    Article  ADS  CAS  Google Scholar 

  5. Weiss, R. et al. Nature 324, 572–575 (1986).

    Article  ADS  CAS  Google Scholar 

  6. Mitsuya, H. & Broder, S. Nature 325, 773–778 (1987).

    Article  ADS  CAS  Google Scholar 

  7. Smith, D. et al. Science 328, 1704–1707 (1987).

    Article  ADS  Google Scholar 

  8. Sattentau, Q. & Weiss, R. Cell 52, 631–633 (1988).

    Article  CAS  Google Scholar 

  9. Janeway, C. Nature 335, 208–210 (1988).

    Article  ADS  Google Scholar 

  10. Dalgleish, A. et al. Nature 312, 763–767 (1984).

    Article  ADS  CAS  Google Scholar 

  11. Klalzmann, D. et al. Nature 312, 767–768 (1984).

    Article  ADS  Google Scholar 

  12. Maddon, P. et al. Cell 47, 333–348 (1986).

    Article  CAS  Google Scholar 

  13. McDougal, J. et al. Science 231, 382–385 (1986).

    Article  ADS  CAS  Google Scholar 

  14. Fisher, R. et al. Nature 331, 76–78 (1988).

    Article  ADS  CAS  Google Scholar 

  15. Hussey, R. et al. Nature 331, 78–81 (1988).

    Article  ADS  CAS  Google Scholar 

  16. Deen, K. et al. Nature 331, 82–84 (1988).

    Article  ADS  CAS  Google Scholar 

  17. Traunecker, A., Luke, W. & Karjalainen, K. Nature 331, 84–86 (1988).

    Article  ADS  CAS  Google Scholar 

  18. Berger, E., Fuerst, T. & Moss, B. Proc. natn. Acad. Sci. U.S.A. 85, 2357–2361 (1988).

    Article  ADS  CAS  Google Scholar 

  19. Siliciano, R. et al. Cell 54, 561–575 (1988).

    Article  CAS  Google Scholar 

  20. Doyle, C. & Strominger, J. Nature 330, 256–259 (1987).

    Article  ADS  CAS  Google Scholar 

  21. Maddon, P. et al. Cell 42, 93–104 (1985).

    Article  CAS  Google Scholar 

  22. Clark, S., Jefferies, W., Barclay, A., Gagnon, J. & Williams, A. Proc. natn. Acad. Sci. U.S.A. 84, 1649–1653 (1987).

    Article  ADS  CAS  Google Scholar 

  23. Dorai, H. & Moore, G. J. Immun. 139, 4232–4241 (1987).

    CAS  PubMed  Google Scholar 

  24. Nakamura, R., Speigelberg, H., Lee, S. & Wiegle, W. J. Immun. 100, 376–383 (1968).

    CAS  PubMed  Google Scholar 

  25. Mordenti, J. J. Pharmaceut. Sci. 75, 1028–1040 (1986).

    Article  CAS  Google Scholar 

  26. Burton, D. Molec. Immun. 22, 161–206 (1985).

    Article  CAS  Google Scholar 

  27. Duncan, A. & Winter, G. Nature 332, 738–740 (1988).

    Article  ADS  CAS  Google Scholar 

  28. Duncan, A., Woof, J., Partridge, L., Burton, D. & Winter, G. Nature 332, 563–564 (1988).

    Article  ADS  CAS  Google Scholar 

  29. Leatherbarrow, R. & Dwek, R. Molec. Immun. 21, 321–327 (1984).

    Article  CAS  Google Scholar 

  30. Feinstein, A., Richardson, N. & Taussig, M. J. Immun. Today 7, 169–174 (1986).

    Article  CAS  Google Scholar 

  31. Gallo, R. et al. Science 224, 500–505 (1984).

    Article  ADS  CAS  Google Scholar 

  32. Mitsuya, H. & Broder, S. Proc. natn. Acad. Sci. U.S.A. 83, 1911–1915 (1986).

    Article  ADS  CAS  Google Scholar 

  33. Homsy, J., Tateno, M. & Levy, J. Lancet i, 1285–1286 (1988).

    Google Scholar 

  34. Takeda, A., Tuazon, C. & Ennis, F. Science 242, 580–583 (1988).

    Article  ADS  CAS  Google Scholar 

  35. Gartner, S. et al. Science 233, 215–219 (1986).

    Article  ADS  CAS  Google Scholar 

  36. Lane, H. & Fauci, A. A. Rev. Immun. 3, 477–500 (1985).

    Article  CAS  Google Scholar 

  37. Harper, M., Marselle, L., Gallo, R. & Wong-Staal, F. Proc. natn. Acad. Sci. U.S.A. 83, 772–776 (1986).

    Article  ADS  CAS  Google Scholar 

  38. Duesberg, P. Science 241, 514 (1988).

    Article  ADS  CAS  Google Scholar 

  39. Lifson, J., Reyes, G., McGrath, M., Stein, B. & Engelman, E. Science 232, 1123–1127 (1986).

    Article  ADS  CAS  Google Scholar 

  40. Sodroski, J., Goh, W., Rosen, C., Campbell, K. & Haseltine, W. Nature 322, 470–474 (1986).

    Article  ADS  CAS  Google Scholar 

  41. Schneider, I., Kaaden, O., Copeland, T. D., Oroslan, S. & Hunsmann, G. J. gen Virol. 67, 2533–2539 (1986).

    Article  CAS  Google Scholar 

  42. Lynette, G., Hartzman, R., Ledbetter, J. & June, C. Science 241, 573–576 (1988).

    Article  ADS  Google Scholar 

  43. Kornfeld, H., Cruikshank, W., Pyle, S., Berman, J. & Center, D. Nature 335, 445–448 (1988).

    Article  ADS  CAS  Google Scholar 

  44. Lyerly, H. Matthews, T., Langlois, A., Bolognesi, D. & Weinhold, K. Proc. natn. Acad. Sci. U.S.A. 84, 4601–4605 (1987).

    Article  ADS  CAS  Google Scholar 

  45. Lanzavecchia, A., Roosneck, E., Gregory, T., Berman, P. & Abrignani, S. Nature 334, 530–532 (1988).

    Article  ADS  CAS  Google Scholar 

  46. Sethi, K., Naher, H. & Stroehmann, I. Nature 335, 178–181 (1988).

    Article  ADS  CAS  Google Scholar 

  47. Ellison, J. P., Berson, B. J. & Hood, L. E. Nucleic Acids Res. 10, 4071–4079 (1982).

    Article  CAS  Google Scholar 

  48. Zoller, M. & Smith, M. Nucleic Acids Res. 10, 6487–6500 (1982).

    Article  CAS  Google Scholar 

  49. Muesing, M., Smith, D. & Capon, D. Cell 48, 691–701 (1987).

    Article  CAS  Google Scholar 

  50. Lasky, L. et al. Cell 50, 975–985 (1987).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Biology, Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, California, 94080, USA

    Daniel J. Capon, Scot A. Marsters & Douglas H. Smith

  2. Department of Recovery Process Research and Development, Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, California, 94080, USA

    Steven M. Chamow & Timothy Gregory

  3. Department of Pharmacological Sciences, Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, California, 94080, USA

    Joyce Mordenti & Hiroaki Mitsuya

  4. Department of Medicinal and Analytical Chemistry, Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, California, 94080, USA

    Catherine Lucas

  5. Department of Cell Culture Research and Development, Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, California, 94080, USA

    Florian M. Wurm

  6. The Clinical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Samuel Broder

  7. Division of Hematology-Oncology, Harvard Medical School, New England Deaconess Hospital, Boston, Massachusetts, 02215, USA

    Randal A. Byrn & Jerome E. Groopman

Authors
  1. Daniel J. Capon
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Steven M. Chamow
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Joyce Mordenti
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Scot A. Marsters
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Timothy Gregory
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hiroaki Mitsuya
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Randal A. Byrn
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Catherine Lucas
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Florian M. Wurm
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Jerome E. Groopman
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Samuel Broder
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Douglas H. Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Capon, D., Chamow, S., Mordenti, J. et al. Designing CD4 immunoadhesins for AIDS therapy. Nature 337, 525–531 (1989). https://doi.org/10.1038/337525a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/337525a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing