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Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells

Nature volume 336, pages 690–692 (1988)Cite this article

Abstract

Leukaemia inhibitory factor (LIF) is a cytokine that induces macrophage differentiation of the murine Ml myeloid leukaemia cell line1,2. We have isolated a cDNA clone encoding a novel human haemopoietic growth factor, human interleukin for DA cells (HILDA) that supports the proliferation of the murine interleukin-3-dependent leukaemic cell line, DA-la (refs 3–5). HILDA proved to be identical to LIF. The demonstration that the differentiation factor LIF will also serve as a growth factor for at least one myeloid leukaemic cell line provides further evidence that the distinction between growth-promoting and differentiation-inducing activities are largely determined by the target cell type.

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Author notes

  1. Jean-Francois Moreau: Institut National de la Santé et de la Recherche Medicale (U 211-Unité de Recherche sur les Effecteurs Lymphocytaires T), Faculté de Medecine; Centre National de la Recherche Scientifique; and Centre Hopitalier Regional de Nantes, France

Authors and Affiliations

  1. Genetics Institute Inc., 87 Cambridge Park Drive, Cambridge, Massachusetts, 02140, USA

    Jean-Francois Moreau, Debra D. Donaldson, Frances Bennett, JoAnn Witek-Giannotti, Steven C. Clark & Gordon G. Wong

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  1. Jean-Francois Moreau
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  2. Debra D. Donaldson
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  3. Frances Bennett
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  4. JoAnn Witek-Giannotti
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  5. Steven C. Clark
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  6. Gordon G. Wong
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Moreau, JF., Donaldson, D., Bennett, F. et al. Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells. Nature 336, 690–692 (1988). https://doi.org/10.1038/336690a0

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