Abstract
Leukaemia inhibitory factor (LIF) is a cytokine that induces macrophage differentiation of the murine Ml myeloid leukaemia cell line1,2. We have isolated a cDNA clone encoding a novel human haemopoietic growth factor, human interleukin for DA cells (HILDA) that supports the proliferation of the murine interleukin-3-dependent leukaemic cell line, DA-la (refs 3–5). HILDA proved to be identical to LIF. The demonstration that the differentiation factor LIF will also serve as a growth factor for at least one myeloid leukaemic cell line provides further evidence that the distinction between growth-promoting and differentiation-inducing activities are largely determined by the target cell type.
Access options
Subscribe to Journal
Get full journal access for 1 year
$199.00
only $3.90 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
from$8.99
All prices are NET prices.
References
- 1
Gearing, D. P. et al. EMBO J. 6, 3995–4002 (1987).
- 2
Gough, N. M. et al. Proc. natn. Acad. Sci. U.S.A. 85, 2623–2627 (1988).
- 3
Moreau, J. F., Bonneville, M. Petrat, M. A., Jacques, Y. & Soulillo, J. P. Annls Inst. Pasteur/ Immun. 137, 25–37 (1986).
- 4
Moreau, J-F. et al. J. Immun. 138, 3844–3849 (1987).
- 5
Godard, A. et al. Blood 71, 1618–1623 (1988).
- 6
Arya, S. K., Wong-Staal, F. & Gallo, R. C. Science 223, 1086–1087 (1984).
- 7
Moreau, J. F. et al. J. clin. Invest. 78, 874 (1986).
- 8
Ihle, J. N., Rein, A. & Mural, R. in Advances in Viral Oncology Vol. 4 (ed. Klein, G.) (Raven, New York, 1984).
- 9
Yang, Y. C. et al. Cell 47, 3–10 (1986).
- 10
Gazdar, A. F. et al. Cancer Res. 40, 3502–3507 (1980).
- 11
Gearing, D. P., King, J. A. & Gough, N. M. Nucleic Acids Res. 16, 9857 (1988).
- 12
Nicola, N. A., Metcalf, D., Masumoto, M. & Johnson, G. R. J. biol. Chem. 258, 9017–9023 (1983).
- 13
Metcalf, D. Int. J. Cancer 25, 616–623 (1979).
- 14
Tomida, M., Yamamoto-Yamaguchi, Y. Hozumi, M., Okabe, T. & Takaka, F. FEBS Lett. 207, 271–275 (1986).
- 15
Shabo, Y. et al. Blood (in the press).
- 16
Smith, A. G. et al. Nature 33, 688–690 (1988).
- 17
Wong, G. G. et al. J. Immun. 140, 3040–3044 (1988).
- 18
Shaw, J., Meerovitch, K., Elliott, J. F., Bleackley, R. C. & Paetkau, V. Molec. Immun. 24, 409–419 (1987).
- 19
Shaw G. & Kamen R. Cell 46, 659–667 (1986).
- 20
Messing, J. & Vieira, J. Gene 19, 269–276 (1982).
- 21
Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).
- 22
Laemmli, U. K. Nature 227, 680–685 (1970).
Author information
Affiliations
Rights and permissions
About this article
Cite this article
Moreau, JF., Donaldson, D., Bennett, F. et al. Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells. Nature 336, 690–692 (1988). https://doi.org/10.1038/336690a0
Received:
Accepted:
Issue Date:
Further reading
-
High expression of bone morphogenetic protein 1 (BMP1) is associated with a poor survival rate in human gastric cancer, a dataset approaches
Genomics (2020)
-
Leukaemia Inhibitory Factor (LIF) Inhibits Cancer Stem Cells Tumorigenic Properties through Hippo Kinases Activation in Gastric Cancer
Cancers (2020)
-
Leukemia inhibitory factor: A main controller of breast cancer
Journal of Biosciences (2020)
-
Leukemia inhibitory factor signaling in Xenopus embryo: Insights from gain of function analysis and dominant negative mutant of the receptor
Developmental Biology (2019)
-
Stem Cell Factor LIFted as a Promising Clinical Target for Cancer Therapy
Molecular Cancer Therapeutics (2019)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
