Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells


Leukaemia inhibitory factor (LIF) is a cytokine that induces macrophage differentiation of the murine Ml myeloid leukaemia cell line1,2. We have isolated a cDNA clone encoding a novel human haemopoietic growth factor, human interleukin for DA cells (HILDA) that supports the proliferation of the murine interleukin-3-dependent leukaemic cell line, DA-la (refs 3–5). HILDA proved to be identical to LIF. The demonstration that the differentiation factor LIF will also serve as a growth factor for at least one myeloid leukaemic cell line provides further evidence that the distinction between growth-promoting and differentiation-inducing activities are largely determined by the target cell type.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Gearing, D. P. et al. EMBO J. 6, 3995–4002 (1987).

    CAS  Article  Google Scholar 

  2. 2

    Gough, N. M. et al. Proc. natn. Acad. Sci. U.S.A. 85, 2623–2627 (1988).

    ADS  CAS  Article  Google Scholar 

  3. 3

    Moreau, J. F., Bonneville, M. Petrat, M. A., Jacques, Y. & Soulillo, J. P. Annls Inst. Pasteur/ Immun. 137, 25–37 (1986).

    Article  Google Scholar 

  4. 4

    Moreau, J-F. et al. J. Immun. 138, 3844–3849 (1987).

    CAS  PubMed  Google Scholar 

  5. 5

    Godard, A. et al. Blood 71, 1618–1623 (1988).

    CAS  PubMed  Google Scholar 

  6. 6

    Arya, S. K., Wong-Staal, F. & Gallo, R. C. Science 223, 1086–1087 (1984).

    ADS  CAS  Article  Google Scholar 

  7. 7

    Moreau, J. F. et al. J. clin. Invest. 78, 874 (1986).

    CAS  Article  Google Scholar 

  8. 8

    Ihle, J. N., Rein, A. & Mural, R. in Advances in Viral Oncology Vol. 4 (ed. Klein, G.) (Raven, New York, 1984).

    Google Scholar 

  9. 9

    Yang, Y. C. et al. Cell 47, 3–10 (1986).

    CAS  Article  Google Scholar 

  10. 10

    Gazdar, A. F. et al. Cancer Res. 40, 3502–3507 (1980).

    CAS  PubMed  Google Scholar 

  11. 11

    Gearing, D. P., King, J. A. & Gough, N. M. Nucleic Acids Res. 16, 9857 (1988).

    CAS  Article  Google Scholar 

  12. 12

    Nicola, N. A., Metcalf, D., Masumoto, M. & Johnson, G. R. J. biol. Chem. 258, 9017–9023 (1983).

    CAS  PubMed  Google Scholar 

  13. 13

    Metcalf, D. Int. J. Cancer 25, 616–623 (1979).

    Article  Google Scholar 

  14. 14

    Tomida, M., Yamamoto-Yamaguchi, Y. Hozumi, M., Okabe, T. & Takaka, F. FEBS Lett. 207, 271–275 (1986).

    CAS  Article  Google Scholar 

  15. 15

    Shabo, Y. et al. Blood (in the press).

  16. 16

    Smith, A. G. et al. Nature 33, 688–690 (1988).

    ADS  Article  Google Scholar 

  17. 17

    Wong, G. G. et al. J. Immun. 140, 3040–3044 (1988).

    CAS  PubMed  Google Scholar 

  18. 18

    Shaw, J., Meerovitch, K., Elliott, J. F., Bleackley, R. C. & Paetkau, V. Molec. Immun. 24, 409–419 (1987).

    CAS  Article  Google Scholar 

  19. 19

    Shaw G. & Kamen R. Cell 46, 659–667 (1986).

    CAS  Article  Google Scholar 

  20. 20

    Messing, J. & Vieira, J. Gene 19, 269–276 (1982).

    CAS  Article  Google Scholar 

  21. 21

    Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).

    ADS  CAS  Article  Google Scholar 

  22. 22

    Laemmli, U. K. Nature 227, 680–685 (1970).

    ADS  CAS  Article  Google Scholar 

Download references

Author information



Rights and permissions

Reprints and Permissions

About this article

Cite this article

Moreau, JF., Donaldson, D., Bennett, F. et al. Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells. Nature 336, 690–692 (1988). https://doi.org/10.1038/336690a0

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing