Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells

Article metrics

Abstract

Leukaemia inhibitory factor (LIF) is a cytokine that induces macrophage differentiation of the murine Ml myeloid leukaemia cell line1,2. We have isolated a cDNA clone encoding a novel human haemopoietic growth factor, human interleukin for DA cells (HILDA) that supports the proliferation of the murine interleukin-3-dependent leukaemic cell line, DA-la (refs 3–5). HILDA proved to be identical to LIF. The demonstration that the differentiation factor LIF will also serve as a growth factor for at least one myeloid leukaemic cell line provides further evidence that the distinction between growth-promoting and differentiation-inducing activities are largely determined by the target cell type.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Gearing, D. P. et al. EMBO J. 6, 3995–4002 (1987).

  2. 2

    Gough, N. M. et al. Proc. natn. Acad. Sci. U.S.A. 85, 2623–2627 (1988).

  3. 3

    Moreau, J. F., Bonneville, M. Petrat, M. A., Jacques, Y. & Soulillo, J. P. Annls Inst. Pasteur/ Immun. 137, 25–37 (1986).

  4. 4

    Moreau, J-F. et al. J. Immun. 138, 3844–3849 (1987).

  5. 5

    Godard, A. et al. Blood 71, 1618–1623 (1988).

  6. 6

    Arya, S. K., Wong-Staal, F. & Gallo, R. C. Science 223, 1086–1087 (1984).

  7. 7

    Moreau, J. F. et al. J. clin. Invest. 78, 874 (1986).

  8. 8

    Ihle, J. N., Rein, A. & Mural, R. in Advances in Viral Oncology Vol. 4 (ed. Klein, G.) (Raven, New York, 1984).

  9. 9

    Yang, Y. C. et al. Cell 47, 3–10 (1986).

  10. 10

    Gazdar, A. F. et al. Cancer Res. 40, 3502–3507 (1980).

  11. 11

    Gearing, D. P., King, J. A. & Gough, N. M. Nucleic Acids Res. 16, 9857 (1988).

  12. 12

    Nicola, N. A., Metcalf, D., Masumoto, M. & Johnson, G. R. J. biol. Chem. 258, 9017–9023 (1983).

  13. 13

    Metcalf, D. Int. J. Cancer 25, 616–623 (1979).

  14. 14

    Tomida, M., Yamamoto-Yamaguchi, Y. Hozumi, M., Okabe, T. & Takaka, F. FEBS Lett. 207, 271–275 (1986).

  15. 15

    Shabo, Y. et al. Blood (in the press).

  16. 16

    Smith, A. G. et al. Nature 33, 688–690 (1988).

  17. 17

    Wong, G. G. et al. J. Immun. 140, 3040–3044 (1988).

  18. 18

    Shaw, J., Meerovitch, K., Elliott, J. F., Bleackley, R. C. & Paetkau, V. Molec. Immun. 24, 409–419 (1987).

  19. 19

    Shaw G. & Kamen R. Cell 46, 659–667 (1986).

  20. 20

    Messing, J. & Vieira, J. Gene 19, 269–276 (1982).

  21. 21

    Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).

  22. 22

    Laemmli, U. K. Nature 227, 680–685 (1970).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.