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A human lymphoid- specific transcription factor that activates immunoglobulin genes is a homoeobox protein

Abstract

The human lymphoid-specific transcription factor OTF-2 contains a homoeodomain that is required for DNA binding and binds specifically to DNA elements that are recognized by Drosophila homoeodomain proteins, suggesting coevolutionary relationships between mammalian and invertebrate homoeodomain proteins and their DNA recognition elements.

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References

  1. 1

    Harvey, R. P., Robins, A. J. & Wells, J. R. E. Nucleic Acids Res. 10, 7851–7863 (1982).

    CAS  Article  Google Scholar 

  2. 2

    Falkner, F. G. & Zachau, H. G. Nature 310, 71–74 (1984).

    ADS  CAS  Article  Google Scholar 

  3. 3

    Parslow, T. G., Blair, D. L., Murphy, W. J. & Granner, D. K. Proc. natn. Acad. Sci. U.S.A. 81, 2650–2654 (1984).

    ADS  CAS  Article  Google Scholar 

  4. 4

    Mizushima-Sugano, J. & Roeder, R. G. Proc. natn. Acad. Sci. U.S.A. 83, 8511–8515 (1986).

    ADS  CAS  Article  Google Scholar 

  5. 5

    Wirth, T., Staudt, L. & Baltimore, D. Nature 329, 174–178 (1987).

    ADS  CAS  Article  Google Scholar 

  6. 6

    Dreyfus, M., Doyen, N. & Rougeon, F. EMBO J. 6, 1685–1690 (1987).

    CAS  Article  Google Scholar 

  7. 7

    Gerster, T., Matthias, P., Thali, M., Jiricny, J. & Schaffner, W. EMBO J. 6, 1323–1330 (1987).

    CAS  Article  Google Scholar 

  8. 8

    Lenardo, M., Pierce, J. W. & Baltimore, D. Science 236, 1573–1577 (1987).

    ADS  CAS  Article  Google Scholar 

  9. 9

    Landolfi, N. F., Capra, J. D. & Tucker, P. W. Nature 323, 548–551 (1986).

    ADS  CAS  Article  Google Scholar 

  10. 10

    Staudt, L. M. et al Nature 323, 640–643 (1986).

    ADS  CAS  Article  Google Scholar 

  11. 11

    Scheidereit, C., Heguy, A. & Roeder, R. G. Cell 51, 783–793 (1987).

    CAS  Article  Google Scholar 

  12. 12

    LaBella, F., Sive, H. L., Roeder, R. G. & Heintz, N. Genes Dev. 2, 32–39 (1988).

    CAS  Article  Google Scholar 

  13. 13

    Pruijn, G. J. M., van Driel, W. & van der Vliet, P. C. Nature 322, 656–659 (1986).

    ADS  CAS  Article  Google Scholar 

  14. 14

    Singh, H., Sen, R., Baltimore, D. & Sharp, P. Nature 319, 154–157 (1986).

    ADS  CAS  Article  Google Scholar 

  15. 15

    Fletcher, C., Heintz, N. & Roeder, R. G. Cell 51, 773–781 (1987).

    CAS  Article  Google Scholar 

  16. 16

    Sturm, R., Baumruker, B. R., Franza, J. R. & Herr, W. Genes Dev. 1, 1147–1160 (1987).

    CAS  Article  Google Scholar 

  17. 17

    Evans, R. M. Science 240, 889–895 (1988).

    ADS  CAS  Article  Google Scholar 

  18. 18

    Ginsberg, A. M., King, B. O. & Roeder, R. G. Cell 39, 479–489 (1984).

    CAS  Article  Google Scholar 

  19. 19

    Kadonaga, J. T., Carner, K. R., Masiarz, F. R. & Tjian, R. Cell 51, 1079–1090 (1987).

    CAS  Article  Google Scholar 

  20. 20

    Bohmann, D. et al. Science 238, 1386–1392 (1987).

    ADS  CAS  Article  Google Scholar 

  21. 21

    Landschulz, W. H., Johnson, P. F., Adashi, E. Y., Graves, B. J. & McKnight, S. L. Genes Dev. 2, 786–800 (1988a).

    CAS  Article  Google Scholar 

  22. 22

    Landschulz, W. H., Johnson, P. F. & McKnight, S. L. Science 240, 1759–1764 (1988b).

    ADS  CAS  Article  Google Scholar 

  23. 23

    Gehring, W. Science 236, 1245–1252 (1987).

    ADS  CAS  Article  Google Scholar 

  24. 24

    Schleif, R. Science 241, 1182–1187 (1988).

    ADS  CAS  Article  Google Scholar 

  25. 25

    Staudt, L. M. et al. Science 241, 577–580 (1988).

    ADS  CAS  Article  Google Scholar 

  26. 26

    Desplan, C., Theis, J. & O'Farrell, P. H. Cell 54, 1081–1090 (1988).

    CAS  Article  Google Scholar 

  27. 27

    Hoey, T. & Levine, M. Nature 332, 858–861 (1988).

    ADS  CAS  Article  Google Scholar 

  28. 28

    Johnson, A. D. & Herskowitz, I. Cell 42, 237–247 (1985).

    CAS  Article  Google Scholar 

  29. 29

    Beachy, P., Krasnow, M., Gavis, E. & Hogness, D. Cell (in the press).

  30. 30

    Robertson, M. Nature 327, 556–557 (1987).

    ADS  Article  Google Scholar 

  31. 31

    Gerster, T. & Roeder, R. G. Proc. natn. Acad. Sci. U.S.A. 85, 6347–51 (1988).

    ADS  CAS  Article  Google Scholar 

  32. 32

    Pabo, C. O. & Sauer, R. T. A. Rev. Biochem. 53, 293–321 (1984).

    CAS  Article  Google Scholar 

  33. 33

    Laughon, A. & Scott, M. Nature 310, 25–31 (1984).

    ADS  CAS  Article  Google Scholar 

  34. 34

    Shepherd, J. W. C., McGinnis, W., Carrasco, A. E., De Robertis, E. M. & Gehring, W. J. Nature 310, 70–71 (1984).

    ADS  CAS  Article  Google Scholar 

  35. 35

    Horikoshi, M., Hai, T., Lin, Y. S., Green, M. R. & Roeder, R. G. Cell 54, 1033–1042 (1988).

    CAS  Article  Google Scholar 

  36. 36

    Dressler, G. R. & Gruss, P. Trends Genet. 4, 214–219 (1988).

    CAS  Article  Google Scholar 

  37. 37

    Way, J. C. & Chalfie, M. Cell 54, 5–16 (1988).

    CAS  Article  Google Scholar 

  38. 38

    Miller, A. M., MacKay, V. L. & Nasmyth, K. Nature 314, 598–603 (1985).

    ADS  CAS  Article  Google Scholar 

  39. 39

    Barad, M., Jack, T., Chadwick, R. & McGinnis, W. EMBO J. 7, 2151–2161 (1988).

    CAS  Article  Google Scholar 

  40. 40

    Chirgwin, J. M., Przybyla, A. E., MacDonald, R. J. & Rutter, W. J. Biochemistry 18, 5294–5299 (1979).

    CAS  Article  Google Scholar 

  41. 41

    Lathe, R. J. molec. Biol. 183, 1–12 (1985).

    CAS  Article  Google Scholar 

  42. 42

    Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).

    ADS  CAS  Article  Google Scholar 

  43. 43

    Kawakami, K., Scheidereit, C. & Roeder, R. G. Proc. natn. Acad. Sci. U.S.A. 85, 4700–4704 (1988).

    ADS  CAS  Article  Google Scholar 

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Scheidereit, C., Cromlish, J., Gerster, T. et al. A human lymphoid- specific transcription factor that activates immunoglobulin genes is a homoeobox protein. Nature 336, 551–557 (1988). https://doi.org/10.1038/336551a0

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