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A human lymphoid- specific transcription factor that activates immunoglobulin genes is a homoeobox protein

Nature volume 336, pages 551–557 (1988)Cite this article

Abstract

The human lymphoid-specific transcription factor OTF-2 contains a homoeodomain that is required for DNA binding and binds specifically to DNA elements that are recognized by Drosophila homoeodomain proteins, suggesting coevolutionary relationships between mammalian and invertebrate homoeodomain proteins and their DNA recognition elements.

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Author notes

  1. Claus Scheidereit

    Present address: Otto Warburg Laboratory of Molecular Biology, Max-Planck-Institute for Molecular Genetics, Ihnestrasse 73, 1000, Berlin, 33, FRG

  2. Kiyoshi Kawakami

    Present address: Department of Biology, Jichi Medical School, Yakushiji, Minamikawachi-machi, Kawachi-gun, Tochigi-ken, 329–04, Japan

Authors and Affiliations

  1. Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York, 10021, USA

    Claus Scheidereit, James A. Cromlish, Thomas Gerster, Kiyoshi Kawakami, Carmen-Gloria Balmaceda, R. Alexander Currie & Robert G. Roeder

Authors
  1. Claus Scheidereit
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  2. James A. Cromlish
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  3. Thomas Gerster
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  4. Kiyoshi Kawakami
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  5. Carmen-Gloria Balmaceda
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  6. R. Alexander Currie
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  7. Robert G. Roeder
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Scheidereit, C., Cromlish, J., Gerster, T. et al. A human lymphoid- specific transcription factor that activates immunoglobulin genes is a homoeobox protein. Nature 336, 551–557 (1988). https://doi.org/10.1038/336551a0

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