Abstract
Cytolytic T lymphocytes (CTLs) are generally thought to recognize cellular antigens presented by class I MHC molecules. A number of studies, however, have revealed responses of considerable magni-tude involving both CD8+ and CD4+ CTLs with class II restric-tion1–5, suggesting that class Il-restricted CTLs recognizing exogeneous protein antigens may exist. As class II antigens are normally expressed on limited types of cells such as B cells and macrophages, such CTLs might be expected to exert a suppressive effect on antibody responses. Here we report that stimulation of mouse lymphocytes with a soluble antigen induced CD8+ and CD4+ CTLs specific for the antigen with class II restriction. The specific lysis was far more efficient when target B cells specifically recognized the antigen than when they did not, indicating that the primary targets for these CTLs are probably B cells expressing immunoglobulin receptors reactive for the same antigen molecule. These results suggest that the natural occurrence of such CTLs during immune responses may explain antigen-specific suppression on antibody responses by T cells.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Vidovic, D., Juretic, A., Nagy, Z. A. & Klein, J. Eur. J. lmmun. 1, 499–509 (1981).
Shinohara, N. & Kojima, M. J. Immun. 132, 578–583 (1984).
Shinohara, N. et al. J. Immun. 140, 30–36 (1988).
Golding, H. & Singer, A. J. Immun. 135, 1610–1615 (1985).
Kaplan, D. R., Griffith, R., Braciale, V. L. & Braciale, T. J. Cell. lmmun. 88, 193 (1984).
Watanabe, M., Wegmann, D. R., Ochi, A. & Hozumi, N. Proc. natn. Acad. Sci. U.S.A. 83, 5247–5251 (1986).
Tite, J. P., Powe, M. B. & Ruddle, N. H. J. lmmun. 135, 25–33 (1985).
Watanabe, M., Yoshikawa, M. & Hozumi, N. Immun. Lett. 15, 133–138 (1987).
Ozaki, S., York-Jolley, J., Kawamura, H. & Berzofsky, J. A. Cell. lmmun. 105, 301–316 (1987).
Nakamura, M., Ross, D. T., Briner, T. J. & Gefter, M. L. J. Immun. 136, 44–47 (1986).
Tite, J. P. & Janeway, C. A. Jr Eur. J. Immun. 14, 878–880 (1984).
Staerz, U. D., Karasuyama, H. & Garner, A. M. Nature 329, 449–451 (1987).
Townsend, A. R. M. et al. Cell 44, 959–968 (1986).
Tada, T., Taniguchi, M. & Takemori, T. Immun. Rev. 26, 106–129 (1975).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shinohara, N., Watanabe, M., Sachs, D. et al. Killing of antigen-reactive B cells by class II- restricted, soluble antigen–specific CD8+ cytolytic T lymphocytes. Nature 336, 481–484 (1988). https://doi.org/10.1038/336481a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/336481a0
This article is cited by
-
Specific cytotoxic T cells eliminate cells producing neutralizing antibodies
Nature (1996)
-
CD4−CD8+ T-cell receptor-αβ+ major histocompatibility complex class-II-specific T-cell clones isolated from aged athymic micemajor histocompatibility complex class-II-specific T-cell clones isolated from aged athymic mice
Immunologic Research (1992)
-
Selective killing of hepatitis B envelope antigen-specific B cells by class I-restricted, exogenous antigen-specific T lymphocytes
Nature (1990)
-
Suppression of the immune response by cytotoxic T cells
Nature (1988)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
