Abstract
Wilms' tumour (WT), a paediatric renal neoplasm, affects approximately 1 in 10,000 children. One or both kidneys can be affected and 5–10% of tumours are bilateral1. Most tumours occur sporadically; however, around 1% of the cases are familial, with siblings or cousins most often being affected2. Familial cases are more frequently bilateral3, and familial and bilateral tumours are diagnosed at an earlier age1. On the basis of these observations, it was proposed that the development of WT requires two mutations4. In most sporadic unilateral WT, both are somatic; in familial and bilateral tumours the first is thought to be germinal. Cytogenetic and molecular studies have demonstrated germinal mutations in WT/aniridia patients and somatic mutations in sporadic WT at chromosomal band 11p13. To investigate whether familial predisposition to WT is due to a germinal 11p13 mutation, we studied a WT family with seven DNA markers that span the 11p13region. We found that familial WT predisposition was not genetically linked to any of the 11p13 markers. This suggests that the gene involved in familial WT predisposition is outside 11p13 and is distinct from the gene involved in tumorigensis and in WT predisposition in WT/aniridia 11p13-deletion patients.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Breslow, N. E. & Beckwith, J. B. J. natn. Cancer Inst. 68, 429–436 (1982).
Matsunaga, E. Hum. Genet. 57, 231–246 (1981).
Strong, L. C. in Clinical Pediatric Oncology 3rd edn (eds Sutow, W. W., Vietti, T. J. & Fernbach, D. J.) 14–41 (Mosby, St Louis, 1984).
Knudson, A. G. & Strong, L. C. J. natn. Cancer Inst. 48, 313–324 (1972).
Riccardi, V. M. et al. Pediatrics 61, 604–610 (1978).
Kaneko, Y., Egues, M. C. & Rowley, J. D. Cancer Res. 41, 4577–4578 (1981).
Slater, R. M. & de Kraker, J. Cancer Genet. Cytogenet. 5, 237–245 (1982).
Fearon, E. R., Vogelstein, B. & Feinberg, A. P. Nature 309, 176–178 (1984).
Koufos, A. et al. Nature 309, 170–172 (1984).
Orkin, S. H., Goldman, D. S. & Sallan, S. E. Nature 309, 172–174 (1984).
Reeve, A. E. et al. Nature 309, 174–176 (1984).
Raizis, A. M., Becroft, D. M., Shaw, R. L. & Reeve, A. E. Hum. Genet. 70, 344–346 (1985).
Dao, D. D. et al. Am. J. hum. Genet. 41, 202–217 (1987).
Shih, C. & Weinberg, R. A. Cell 29, 161–169.
Bell, G. I., Karam, J. H. & Rutter, W. J. Proc. natn. Acad. Sci. U.S.A. 78, 5759–5763 (1981).
Hendy, G. N., Kronenberg, H. M., Potts, J. T. Jr & Rich, A. Proc. natn. Acad. Sci. U.S.A. 78, 7365–7369 (1981).
Compton, D. A. et al. Cell (in the press).
Kidd, J. R., Castiglione, C. M., Pakstis, A. J. & Kidd, K. K. Cytogenet. Cell Genet. 45, 63–64 (1987).
Ott, J. Analysis of Human Genetic Linkage (Johns Hopkins University Press, Baltimore, 1985).
Koufos, A. et al. Nature 316, 330–334 (1985).
Narahara, K. et al. Hum. Genet. 66, 181–185 (1984).
Yunis, J. J. & Ramsay, N. K. C. Pediatrics 96, 1027–1030 (1980).
Koussefl, B. G. J. Pediat. 98, 676–677 (1981).
Nakagome, Y. & Nagahara, N. Hum. Genet. 70, 289 (1985).
Breslow, N., Beckwith, J. B., Ciol, M. & Sharpies, K. Cancer Res. 48, 1653–1657 (1988).
Mathew, C. G. P. et al. Nature 328, 524–526 (1987).
Mathew, C. G. P. et al. Nature 328, 527–528 (1987).
Simpson, N. E. et al. Nature 328, 528–530 (1987).
Huff, V. et al. Nucleic Acids Res. 15, 7651 (1987).
Watkins, P. C. et al. DNA 6, 205–212 (1987).
Korneluk, R. G. et al. J. biol. Chem. 22, 13819–13823 (1984).
Feder, J. et al. Am. J. hum. Genet. 37, 635–649 (1985).
Ott, J. Am. J. hum. Genet. 26, 588–597 (1974).
Author information
Authors and Affiliations
Additional information
To whom reprint requests should be addressed.
Rights and permissions
About this article
Cite this article
Huff, V., Compton, D., Chao, LY. et al. Lack of linkage of familial Wilms' tumour to chromosomal band 11 p13. Nature 336, 377–378 (1988). https://doi.org/10.1038/336377a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/336377a0
This article is cited by
-
Hallmark discoveries in the biology of Wilms tumour
Nature Reviews Urology (2024)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.