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Unresponsiveness to a foreign antigen can be caused by self-tolerance

Abstract

In mice, two sets of genes govern the immune response to the synthetic antigen GT. One maps to the major histocompatibility complex and behaves like a typical immune response gene. The second is a background gene encoding a cell surface structure found on B cells. Mice which express, and are therefore tolerant of, one form of this structure do not respond to GT. Thus, tolerance of self generates holes in the T-cell repertoire, partially crippling the immune system.

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Vidović, D., Matzinger, P. Unresponsiveness to a foreign antigen can be caused by self-tolerance. Nature 336, 222–225 (1988). https://doi.org/10.1038/336222a0

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