Neuronal correlate of visual associative long-term memory in the primate temporal cortex

Abstract

In human long-term memory, ideas and concepts become associated in the learning process1. No neuronal correlate for this cognitive function has so far been described, except that memory traces are thought to be localized in the cerebral cortex; the temporal lobe has been assigned as the site for visual experience because electric stimulation of this area results in imagery recall,2 and lesions produce deficits in visual recognition of objects3–9. We previously reported that in the anterior ventral temporal cortex of monkeys, individual neurons have a sustained activity that is highly selective for a few of the 100 coloured fractal patterns used in a visual working-memory task10. Here I report the development of this selectivity through repeated trials involving the working memory. The few patterns for which a neuron was conjointly selective were frequently related to each other through stimulus–stimulus association imposed during training. The results indicate that the selectivity acquired by these cells represents a neuronal correlate of the associative long-term memory of pictures.

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References

  1. 1

    Anderson, J. R. & Bower, G. H. Human Associative Memory (Lawrence Erlbaum Associates Hillsdale, 1980).

    Google Scholar 

  2. 2

    Penfield, W. & Perot, P. Brain 86, 595–697 (1963).

    CAS  Article  Google Scholar 

  3. 3

    McCarthy, R. A. & Warrington, E. K. J. Neurol. Neurosurg. Pschiat. 49, 1233–1240 (1986).

    CAS  Article  Google Scholar 

  4. 4

    Kimura, D. Arch. Neurol. 8, 48–55 (1963).

    Article  Google Scholar 

  5. 5

    Milner, B. Neuropsychologia 6, 191–209 (1968).

    Article  Google Scholar 

  6. 6

    Gross, C. G. in Handbook of Sensory Physiology Vol. 8, part 3B (ed. Jung, R.) 451–482 (Springer, Berlin, 1972).

    Google Scholar 

  7. 7

    Mishkin, M. Phil. Trans. R. Soc B298, 85–95 (1982).

    ADS  Article  Google Scholar 

  8. 8

    Gaffan, D. & Weiskrantz, L. Brain Res. 196, 373–386 (1980).

    CAS  Article  Google Scholar 

  9. 9

    Sahgal, A., Hutchison, R., Hughes, R. P. & Iverson, S. D. Behavl Brain Res. 8, 361–373 (1983).

    CAS  Article  Google Scholar 

  10. 10

    Miyashita, Y. & Chang, H. S. Nature 331, 68–70 (1988).

    ADS  CAS  Article  Google Scholar 

  11. 11

    Miyashita, Y. in Competition and Cooperation of Neural Nets Vol. 2 (ed. Arbib, M.) (Springer, Berlin, in the press).

  12. 12

    Miyashita, Y. & Nagao, S. J. Physiol. 351, 251–262 (1984).

    CAS  Article  Google Scholar 

  13. 13

    Snedecor, G. W. & Corcoran, W. G. Statistical Method (Iowa University Press, Iowa, 1980).

    Google Scholar 

  14. 14

    Gross, C. G., Rocha-Miranda, C. E. & Bender, D. B. J. Neurophysiol. 35, 96–111 (1972).

    CAS  Article  Google Scholar 

  15. 15

    Desimone, R., Albright, T. D., Gross, C. G. & Bruce, C. J. Neurosci. 4, 2051–2062 (1984).

    CAS  Article  Google Scholar 

  16. 16

    Rolls, E. T. & Baylis, G. C. Brain Res. 65, 38–48 (1986).

    CAS  Google Scholar 

  17. 17

    Schwartz, E. L., Desimone, R., Albright, T. D. & Gross, C. G. Proc. natn. Acad. Sci. U.S.A. 80, 5776–5778 (1983).

    ADS  CAS  Article  Google Scholar 

  18. 18

    Sato, T., Kawamura, T. & Iwai, E. Expl Brain Res. 38, 313–319 (1980).

    CAS  Article  Google Scholar 

  19. 19

    Turner, B. H., Mishkin, M. & Knapp, M. J. comp. Neurol 191, 515–543 (1980).

    CAS  Article  Google Scholar 

  20. 20

    Seltzer, B. & Pandya, D. N. Brain Res. 149, 1–24 (1978).

    CAS  Article  Google Scholar 

  21. 21

    Herzog, A. G. & Van Hoesen, G. W. Brain Res. 115, 57–69 (1976).

    CAS  Article  Google Scholar 

  22. 22

    Van Hoesen, G. W. & Pandya, D. N. Brain Res. 95, 1–24 (1975).

    CAS  Article  Google Scholar 

  23. 23

    Yukie, M. Neurosci. Res. Suppl. 7, S16 (1988).

  24. 24

    Jones, E. G. & Powell, T. P. S. Brain 93, 793–820 (1970).

    CAS  Article  Google Scholar 

  25. 25

    Perret, D. I., Mistlin, A. J. & Chitty, A. J. Trends Neurosci. 10, 358–364 (1987).

    Article  Google Scholar 

  26. 26

    Baylis, G. C., Hasselmo, M. E. & Rolls, E. T. Soc. Neurosci. Abstr. 13, 1317 (1987).

    Google Scholar 

  27. 27

    Hecaen, H., Goldblum, M. C., Masure, M. C. & Ramier, A. M. Neuropsychologia 12, 447–464 (1974).

    CAS  Article  Google Scholar 

  28. 28

    Marshall, J. C. Nature 334, 378 (1988).

    ADS  CAS  Article  Google Scholar 

Download references

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Miyashita, Y. Neuronal correlate of visual associative long-term memory in the primate temporal cortex. Nature 335, 817–820 (1988). https://doi.org/10.1038/335817a0

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