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Repetitive spikes in cytoplasmic calcium evoked by histamine in human endothelial cells

Nature volume 335, pages 40–45 (1988)Cite this article

Abstract

Measurement of cytoplasmic free calcium, [Ca2+]i, in single human endothelial cells has shown that low doses of the inflammatory mediator histamine evoke asynchronous repetitive spikes in [Ca2+]i whereas high doses cause a maintained elevated [Ca2+]i. We discuss possible regulatory mechanisms, and the potential physiological and pathological implications of such a frequency-modulated [Ca2+]i signalling system.

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Authors and Affiliations

  1. Smith Kline & French Research Limited, The Frythe, Welwyn, Hertfordshire, AL6 9AR, UK

    Ron Jacob, Janet E. Merritt, Trevor J. Hallam & Timothy J. Rink

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  1. Ron Jacob
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  2. Janet E. Merritt
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  3. Trevor J. Hallam
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  4. Timothy J. Rink
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Jacob, R., Merritt, J., Hallam, T. et al. Repetitive spikes in cytoplasmic calcium evoked by histamine in human endothelial cells. Nature 335, 40–45 (1988). https://doi.org/10.1038/335040a0

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