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Spliceosomal RNA U6 is remarkably conserved from yeast to mammals

Nature volume 334, pages 213–218 (1988)Cite this article

Abstract

The small nuclear RNA U6 and its gene have been isolated from yeast. In striking contrast to other yeast spliceosomal RNAs, U6 is very similar in size, sequence and structure to its mammalian homologue. The single-copy gene is essential. These properties suggest a central role in pre-mRNA processing. An extensive base-pairing interaction with U4 snRNA is described; the destabilization of the U4/U6 complex seen during splicing thus requires a large conformational change.

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California, 94143, USA

    David A. Brow & Christine Guthrie

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  1. David A. Brow
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  2. Christine Guthrie
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Brow, D., Guthrie, C. Spliceosomal RNA U6 is remarkably conserved from yeast to mammals. Nature 334, 213–218 (1988). https://doi.org/10.1038/334213a0

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