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Function of a yeast TATA element-binding protein in a mammalian transcription system

Nature volume 334, pages 37–42 (1988)Cite this article

Abstract

Saccharomyces cerevisiae contains a protein which is functionally similar to the mammalian TATA element-binding transcription factor, TFIID. The yeast factor substitutes for TFIID in a mammalian RNA polymerase II in vitro transcription system, forms a stable preinitiation complex on the Adenovirus-2 major late promoter, and binds specifically to the TATA boxes of the viral promoter and the yeast CYCl promoter. Interestingly, the yeast factor promotes initiation at a distance from the TATA element typical of a mammalian system.

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Authors and Affiliations

  1. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Steven Hahn & Leonard Guarente

  2. Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Stephen Buratowski & Phillip A. Sharp

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  1. Stephen Buratowski
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  2. Steven Hahn
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  3. Phillip A. Sharp
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  4. Leonard Guarente
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Buratowski, S., Hahn, S., Sharp, P. et al. Function of a yeast TATA element-binding protein in a mammalian transcription system. Nature 334, 37–42 (1988). https://doi.org/10.1038/334037a0

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