Stimulation of B-cell progenitors by cloned murine interleukin-7

Abstract

The events involved in the commitment and development of lymphoid lineage cells are poorly understood. We have used a recently described long-term culture system1 to establish a bioassay that can detect a novel growth factor capable of stimulating the proliferation of lymphoid progenitors2. Using direct expression in mammalian cells we have isolated a complementary DNA clone encoding this novel haematopoietic growth factor, designated interleukin-7.

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Namen, A., Lupton, S., Hjerrild, K. et al. Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature 333, 571–573 (1988). https://doi.org/10.1038/333571a0

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