Article | Published:

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

Nature volume 332, pages 411415 (31 March 1988) | Download Citation

Subjects

Abstract

An endothelium-derived 21-residue vasoconstrictor peptide, endothelin, has been isolated, and shown to be one of the most potent vasoconstrictors known. Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelin is an endogenous modulator of voltage-dependent ion channels. Expression of the endothelin gene is regulated by several vasoactive agents, indicating the existence of a novel cardiovascular control system.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    & Nature 288, 373–376 (1980).

  2. 2.

    Circ. Res. 53, 557–573 (1983).

  3. 3.

    A. Rev. Pharmac. Toxicol. 24, 175–197 (1984).

  4. 4.

    , & Nature 327, 524–526 (1987).

  5. 5.

    & Circ. Res. 51, 439–447 (1982).

  6. 6.

    & J. Physiol, Lond. 364, 45–56 (1985).

  7. 7.

    & Expl Lung Res. 7, 101–112 (1984).

  8. 8.

    Circ. Res. 60, 102–107 (1987).

  9. 9.

    , & Am. J. Physiol. 252, H671–H673 (1987).

  10. 10.

    & J. Physiol., Lond. 335, 65–74 (1983).

  11. 11.

    & Eur. J. Pharmac. 138, 445–446 (1987).

  12. 12.

    , , & Am. J. Physiol. 248, C550–C556 (1985).

  13. 13.

    , , & J. Pharmac. exp. Ther. 236, 339–343 (1986).

  14. 14.

    , & J. cell. Physiol. 132, 263–270 (1987).

  15. 15.

    , , & A. Rev. Physiol. 48, 307–320 (1986).

  16. 16.

    , & Pharmac. Rev. 26, 69–123 (1974).

  17. 17.

    Am. J. Physiol. 219, 222–229 (1970).

  18. 18.

    Acta physiol. scand. 125, 33–41 (1986).

  19. 19.

    Nucleic Acids Res. 12, 857–872 (1984).

  20. 20.

    & J. molec. Biol. 167, 391–409 (1983).

  21. 21.

    Essays Biochem. 22, 69–119 (1986).

  22. 22.

    & J. clin. Invest. 59, 684–695 (1977).

  23. 23.

    et al. J. cardiovasc. Pharmac. 6, 1161–1169 (1984).

  24. 24.

    , & Am. J. Physiol. 250, H1145–H1149 (1986).

  25. 25.

    Electron Microscopy in Human Medicine Vol. 5, 87–154 (McGraw–Hill, New York, 1980).

  26. 26.

    Science 177, 314–322 (1972).

  27. 27.

    et al. Science 230, 1338–1343 (1985).

  28. 28.

    et al. Proc. natn. Acad. Sci. U.S.A. 77, 6496–6500 (1980).

  29. 29.

    & Science 227, 1435–1441 (1985).

  30. 30.

    , & FEBS Lett. 181, 211–217 (1985).

  31. 31.

    , & Biochem. biophys. Res. Commun. 95, 1607–1614 (1980).

  32. 32.

    A. Rev. Biochem. 55, 953–985 (1986).

  33. 33.

    et al. Nature 328, 313–318 (1987).

  34. 34.

    & J. Physiol., Paris 78, 681–686 (1983).

  35. 35.

    Blood Vessels 24, 141–144 (1987).

  36. 36.

    New Engl. J. Med. 314, 488–500 (1986).

  37. 37.

    & In Vitro 19, 394–402 (1983).

  38. 38.

    Nucleic Acids Res. 14, 4683–4690 (1986).

  39. 39.

    , & in Atlas of Protein Sequence and Structure Vol. 5, Suppl. 3 (ed. Dayhoff, M. O.) 345–352 (National Biomedical Research Foundation, Silver Spring, Maryland, 1978).

  40. 40.

    , & Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Laboratory, New York, 1982).

  41. 41.

    , & in DNA Cloning: A Practical Approach, Vol. 1 (ed. Glover, D. M.) 49–78 (IRL, Oxford, 1985).

  42. 42.

    J. molec. Biol. 183, 1–12 (1985).

  43. 43.

    et al. Nature 318, 334–338 (1985).

  44. 44.

    , & Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).

  45. 45.

    in Transcription and translation: A Practical Approach (ed. Hames, B. D. & Higgins, S. J.) 211–230 (IRL, Oxford, 1984).

  46. 46.

    & Analyt. Biochem. 132, 6–13 (1983).

Download references

Author information

Author notes

    • Mieko Kobayashi
    •  & Youji Mitsui

    Fermentation Research Institute, Agency of Industrial Science and Technology, Tsukuba, Ibaraki 305, Japan

    • Yoshio Yazaki

    Third Department of Internal Medicine, University of Tokyo, Hongo, Tokyo 113, Japan

    • Hiroki Kurihara

    Present address: Third Department of Internal Medicine, University of Tokyo, Hongo, Tokyo 113, Japan.

    • Tomoh Masaki

    To whom correspondence should be addressed.

Affiliations

  1. Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan

    • Masashi Yanagisawa
    • , Hiroki Kurihara
    • , Sadao Kimura
    • , Yoko Tomobe
    • , Mieko Kobayashi
    • , Youji Mitsui
    • , Yoshio Yazaki
    • , Katsutoshi Goto
    •  & Tomoh Masaki

Authors

  1. Search for Masashi Yanagisawa in:

  2. Search for Hiroki Kurihara in:

  3. Search for Sadao Kimura in:

  4. Search for Yoko Tomobe in:

  5. Search for Mieko Kobayashi in:

  6. Search for Youji Mitsui in:

  7. Search for Yoshio Yazaki in:

  8. Search for Katsutoshi Goto in:

  9. Search for Tomoh Masaki in:

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/332411a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.