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Reshaping human antibodies for therapy

Nature volume 332, pages 323327 (24 March 1988) | Download Citation

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Abstract

A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six hypervariable regions from the heavy- and light-chain variable domains of a rat antibody directed against human lymphocytes. The reshaped human antibody is as effective as the rat antibody in complement and is more effective in cell-mediated lysis of human lymphocytes.

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Author notes

    • Michael Clark
    •  & Herman Waldmann

    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK

    • Lutz Riechmann

    Address from April 1988: Department of Molecular Biology, The Research Institute of Scripps Clinic, North Torrey Pines Road, La Jolla, California 02937, USA

    • Greg Winter

    To whom correspondence should be addressed.

Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK

    • Lutz Riechmann
    • , Michael Clark
    • , Herman Waldmann
    •  & Greg Winter

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https://doi.org/10.1038/332323a0

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