Abstract
The actions of many peptide growth factors include both stimulation and inhibition of cell proliferation, as well as effects unrelated to the control of cell growth. One peptide can have both stimulatory and inhibitory activity in a single cell, depending on the context of the other signal molecules present.
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References
Carpenter, G. & Cohen, S. A. Rev. Biochem. 48, 193–216 (1979).
Panaretto, B. A., Leish, Z., Moore, G. P. & Robertson, D. M. J. Endocr. 100, 25–31 (1984).
Kamata, N. et al. Cancer Res. 46, 1648–1653 (1986).
Gregory, H. Nature 257, 325–327 (1975).
Baird, A. et al. Recent Prog. Horm. Res. 42, 143–205 (1986).
Folkman, J. & Klagsburn, M. Science 235, 442–447 (1987).
Gospodarowicz, D. Nucl. Med. Biol. 14, 421–434 (1987).
Schweigerer, L., Neufeld, G. & Gospodarowicz, D. J. clin. Invest. 80, 1516–1520 (1987).
Sporn, M. B., Roberts, A. B., Wakefield, L. M. & de Crombrugghe, B. J. Cell Biol. 105, 1039–1045 (1987).
Moses, H. L. et al. Cancer Cells 3, 65–71 (1985).
Robey, P. G. et al. J. Cell Biol. 105, 457–463 (1987).
Centrella, M., McCarthy, T. L. & Canalis, E. C. J. biol. Chem. 262, 2869–2874 (1987).
Kehrl, J. H. et al. J. exp. Med. 163, 1037–1050 (1986).
Kehrl, J. H. et al J. Immun. 137, 3855–3860 (1986).
Hotta, M. & Baird, A. Proc. natn. Acad. Sci. U.S.A. 83, 7795–7799 (1986).
Durum, S. K., Schmidt, J. A. & Oppenheim, J. J. A. Rev. Immun. 3, 263–287 (1985).
Gaffney, E. V. & Tsai, S.-C. Cancer Res. 46, 3834–3837 (1986).
Murphy, P. A., Simon, P. L. & Willoughby, W. F. J. Immun. 124, 2498–2501 (1980).
Gowen, M. & Mundy, G. R. J. Immun. 136, 2478–2482 (1986).
Waldmann, T. A. et al. J. exp. Med. 160, 1450–1466 (1984).
Taniguchi, T. et al. Immunol. Rev. 92, 122–133 (1986).
Benveniste, E. N. & Merrill, J. E. Nature 321, 610–613 (1986).
Saneto, R. P., Altman, A., Knobler, R. L., Johnson, H. M. & de Vellis, J. Proc. natn. Acad. Sci. U.S.A. 83, 9221–9225 (1986).
Malkovsky, M. et al. Nature 325, 262–265 (1987).
Van Damme, J. et al. J. exp. Med. 165, 914–919 (1987).
Revel, M. et al. J. Leukocyte Biol. 42, 554 (1987).
Sehgal, P. B., May, L. T., Tamm, I. & Vilček, J. Science 235, 731–732 (1987).
Kishimoto, T. & Hirano, T. A. Rev. Immun. 6, 485–512 (1988).
Sugarman, B. J. et al. Science 230, 943–945 (1985).
Vilček, J. et al. J. exp. Med. 163, 632–643 (1986).
Beutler, B. & Cerami, A. Nature 320, 584–588 (1986).
Paul, W. E. & Ohara, J. A. Rev. Immun. 5, 429–459 (1987).
Mosmann, T. R. et al. Proc. natn. Acad. Sci. U.S.A. 83, 5654–5658 (1986).
Fernandez-Botran, R., Krammer, P. H., Diamenstein, T., Uhr, J. W. & Vitetta, E. J. exp. Med. 164, 580–593 (1986).
Rennick, D. et al. Proc. natn. Acad. Sci. U.S.A. 84, 6889–6893 (1987).
Gurney, M. E., Heinrich, S. P., Lee, M. R. & Yin, H.-S. Science 234, 566–574 (1986).
Gurney, M. E. et al. Science 234, 574–581 (1986).
Poupart, P. et al. EMBO J. 6, 1219–1224 (1987).
Hanley, M. R. Nature 315, 14–15 (1985).
Zachary, I., Woll, P. J. & Rozengurt, E. Devl Biol. 124, 295–308 (1987).
Roberts, A. B. et al. Proc. natn. Acad. Sci. U.S.A. 82, 119–123 (1985).
Centrella, M., McCarthy, T. L. & Canalis, E. FASEB J. 1, 312–317 (1987).
Seyedin, S. M. et al. J. biol. Chem. 261, 5693–5695 (1986).
Rosen, F. M., Stempien, S. A., Thompson, A. Y. & Seyedin, S. M. J. cell. Physiol. (in the press).
Dinarello, C. A. et al. J. exp. Med. 163, 1433–1450 (1986).
Ranges, G. E., Figari, I. S., Espevik, T. & Palladino, M. A. Jr J. exp. Med. 166, 991–998 (1987).
Corvera, S. & Czech, M. P. Proc. natn. Acad. Sci. U.S.A. 82, 7314–7318 (1985).
Rechler, M. M. & Nissley, S. P. A. Rev. Physiol. 47, 425–452 (1985).
Bowen-Pope, D. F., DiCorletto, P. E. & Ross, R. J. Cell Biol. 96, 679–683 (1983).
Zachary, I. & Rozengurt, E. Cancer Surv. 4, 729–765 (1985).
Morgan, D. O. et al. Nature 329, 301–307 (1987).
Lobel, P., Dahms, N. M., Breitmeyer, J., Chirgwin, J. M. & Kornfeld, S. Proc. natn. Acad. Sci. U.S.A. 84, 2233–2237 (1987).
Shannon, C. E. & Weaver, W. The Mathematical Theory of Communication (University of Illinois Press, Urbana, 1949).
Ashby, W. R. An Introduction to Cybernetics (Wiley, New York, 1956).
Rozengurt, E. Science 234, 161–166 (1986).
Bouche, G. et al. Proc. natn. Acad. Sci. U.S.A. 84, 6770–6774 (1987).
Burwen, S. J. & Jones, A. L. Trends biochem. Sci. 12, 159–162 (1987).
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Sporn, M., Roberts, A. Peptide growth factors are multifunctional. Nature 332, 217–219 (1988). https://doi.org/10.1038/332217a0
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DOI: https://doi.org/10.1038/332217a0
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