Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

A new natriuretic peptide in porcine brain

Nature volume 332, pages 78–81 (1988)Cite this article

Abstract

Atrial natriuretic peptide (ANP), a hormone secreted from mammalian atria, regulates the homoeostatic balance of body fluid and blood pressure1–3. ANP-like immunoreactivity is also present in the brain, suggesting that the peptide functions as a neuro-peptide4,5. We report here identification in porcine brain of a novel peptide of 26 amino-acid residues, eliciting a pharmacological spectrum very similar to that of ANP, such as natriuretic-diuretic, hypotensive and chick rectum relaxant activities. The complete amino-acid sequence determined for the peptide is remarkably similar to but definitely distinct from the known sequence of ANP1,3,6, indicating that the genes for the two are distinct. Thus, we have designated the peptide 'brain natriuretic peptide' (BNP). The occurrence of BNP with ANP in mammalian brain suggests the possibility that the physiological functions so far thought to be mediated by ANP may be regulated through a dual mechanism involving both ANP and BNP

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

Buy

All prices are NET prices.

References

  1. Kangawa, K. & Matsuo, H. Biochem. biophys. Res. Commun. 118, 131–139 (1984).

    CAS  Article  Google Scholar 

  2. de Bold, A. J. Science 230, 767–770 (1985).

    ADS  CAS  Article  Google Scholar 

  3. Matsuo, H. & Nakazato, H. Endocrinology Metabolism Clinics of North America, Vol. 16, Atrial Natriuretic Factor (eds Rosenblatt, M. & Jacobs, J. W.) 43–61 (Saunders, Philadelphia 1987).

    Google Scholar 

  4. Samson, W. K. Endocrinology & Metabolism Clinics of North America, Vol. 16, Atrial Natriuretic Factor (eds Rosenblatt, M. & Jacobs, J. W.) 145–161 (Saunders, Philadelphia, 1987).

    Google Scholar 

  5. Nakao, K. et al. J. Hypertension 4, (suppl. 6) 492–496 (1986).

    Google Scholar 

  6. Forssmann, W. G. et al. Cell Tissue Res. 238, 425–430 (1984).

    CAS  Article  Google Scholar 

  7. Currie, M. G. et al. Science 221, 71–73 (1983).

    ADS  CAS  Article  Google Scholar 

  8. Ueda, S. et al. Biochem. biophys. Res. Commun. 149, 1055–1062 (1987).

    CAS  Article  Google Scholar 

  9. Oikawa, S. et al. Nature 309, 724–726 (1984).

    ADS  CAS  Article  Google Scholar 

  10. Oikawa, S. et al. Biochem. biophys. Res. Commun. 132, 892–899 (1985).

    CAS  Article  Google Scholar 

  11. Kangawa, K., Fukuda, A. & Matsuo, H. Nature 313, 397–400 (1985).

    ADS  CAS  Article  Google Scholar 

  12. Miyata, A., Kangawa, K., Toshimori, T. & Matsuo, H. Biochem. biophys. Res. Commun. 129, 248–255 (1985).

    CAS  Article  Google Scholar 

  13. Miyata, A., Toshimori, T., Kangawa, K. & Matsuo, H. Biochem. biophys. Res. Commun. 142, 461–467 (1987).

    CAS  Article  Google Scholar 

  14. Minamino, N., Kangawa, K. & Matsuo, H. Biochem. biophys. Res. Commun. 130, 1078–1085 (1985).

    CAS  Article  Google Scholar 

  15. de Bold, A. J., Borenstein, H. B., Veress, A. T. & Sonnenberg, H. Life Sci. 28, 89–94 (1981).

    CAS  Article  Google Scholar 

  16. Kamber, B. et al. Helv. chim. Acta 63, 899–915 (1980).

    CAS  Article  Google Scholar 

Download references

Author information

Author notes

  1. Hisayuki Matsuo: To whom correspondence should be addressed.

Affiliations

  1. Department of Biochemistry, Miyazaki Medical College, Kiyotake, Miyazaki, 889-16, Japan

    Tetsuji Sudoh, Kenji Kangawa, Naoto Minamino & Hisayuki Matsuo

Authors
  1. Tetsuji Sudoh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kenji Kangawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Naoto Minamino
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hisayuki Matsuo
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sudoh, T., Kangawa, K., Minamino, N. et al. A new natriuretic peptide in porcine brain. Nature 332, 78–81 (1988). https://doi.org/10.1038/332078a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/332078a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing