Abstract
Analysis of complementary DNA encoding a novel gene product reveals striking similarity to the steroid and thyroid hormone receptors. Binding and transcription activational studies show it to be a receptor for the vitamin A-related morphogen retinoic acid.
This is a preview of subscription content
Access options
Subscribe to Journal
Get full journal access for 1 year
204,58 €
only 4,01 € per issue
Tax calculation will be finalised during checkout.
Buy article
Get time limited or full article access on ReadCube.
$32.00
All prices are NET prices.
References
1. Hollenberg, S. M. et al. Nature 318, 635-641 (1985). 2. Green, S. et al. Nature 320, 134-139 (1986). 3. Giguere, V., Hollenberg, S. M., Rosenfeld, M. G. & Evans, R. M. Cell 46, 645-652 (1986). 4. Hollenberg, S. M., Giguere, V., Segui, P. & Evans, R. M. Cell 49, 39 (1987). 5. Green, S. & Chambon, P. Nature 375, 75-78 (1987). 6. Kumar, V., Green, S., Stark, G., Berry, M., Jin, J.-R. & Chambon, P. Cell 51 (in the press). 7. Miesfeld, R., Godowski, P. J., Maler, B. & Yamamoto, K. R. Science 236, 434-427 (1987). 8. Weinberger, C., Hollenberg, S. M., Rosenfeld, M. G. & Evans, R. M. Nature 318, 670-672 (1985). 9. Weinberger, C. et al. Nature 324, 641-646 (1986). 10. Sap, J. et al. Nature 324, 635-640 (1986). 11. Arriza, J. et al. Science 237, 268-275 (1987). 12. Thompson, C. C., Weinberger, C., Lebo, R. & Evans, R. M. Science 237, 1610-1614 (1987). 13. Dejean, A., Bougueleret, L., Grzeschik, K.-H. & Tiollals, P. Nature 322, 70-72 (1986). 14. Kozak, M. Nucleic Acid Res. 16, 8125-8148 (1987). 15. Proudfoot, N. J. & Brownlee, G. G. Nature 263, 211-214 (1976). 16. Krieg, P. A. & Melton, D. A. Nucleic Acid Res. 12, 7057-7070 (1984). 17. Sporn, M. B. & Roberts, A. B. in The Retinoids Vol. 1 (eds Sporn, M. B., Roberts, A. B. & Goodman, D. S.) 235-279 (Academic, New York, 1984). 18. Sporn, M. & Roberts, A. B. Cancer Res. 43, 3034-3040 (1983). 19. Mandel, G. & Cohen, V. in The Pharmacological Basis of Therapeutics (eds Oilman, A., Goodman, L., Rail, T. & Mural, F.) 1573-1591 (Macmillan, New York, 1985). 20. Wolback, S. B. & Howe, P. R. J. exp. Med. 62, 753-777 (1925). 21. Lotan, R. Biochim. biophys. Acta 605, 23-91 (1980). 22. Fuchs, E. & Green, H. Cell 25, 617-625 (1980). 23. Haussler, M. et al. Proc. natn. Acad. Sci. U.S.A. 80, 5525-5529 (1983). 24. Lotan, R., Stolarsky, T. & Lotan, D. Cancer Res. 43, 2868-2875 (1983). 25. Shroder, E., Rapaport, E., Kabeenell, K. & Black, P. H. Proc. natn. Acad. Sci. U.S.A. 79, 1549-1552 (1982). 26. Breitman, T., Selonick, S. & Collins, S. J. Proc. natn. Acad. Sci. U.S.A. 77, 2936-2940 (1980). 27. Strickland, S. & Mahdavl, V. Cell 15, 393-403 (1978). 28. Jetten, A., Jetten, M. & Sherman, M. Expl Cell Res. 124, 381-392 (1979). 29. Wang, S.-Y., LaRosa, G. & Gudas, L. J. Devl Biol. 107, 75-86 (1985). 30. Thaller, C. & Eichele, G. Nature 327, 625-628 (1987). 31. Moon, R. C. & Itri, L. M. in The Retinoids (eds Sporn, M. B., Roberts, A. B., & Goodman, D. S.) 327-371 (Academic, New York, 1984). 32. Chytel, F. & Ong, D. E. in The Retinoids Vol. 2 (eds Sporn, M. B., Roberts, A. B., Goodman, D. S.) 89-123 (Academic, New York, 1984). 33. Sundelin, J., Das, S. R., Eriksson, U., Rask, L. & Peterson, P. A. /. biol. Chem. 260,6494-6499 (1985). 34. Saari, J., Futterman, S. & Bredberg, L. /. biol. Chem. 253, 6432-6436 (1978). 35. Sundelin, J. et al. J. biol. Chem. 260, 6488-6493 (1985). 36. Colantuoni, V. et al. Biochem. biophys. Res. Commun. 130, 431-439 (1985). 37. Bell, G. I. et al. Nucleic Acid Res. 14, 8427-8446 (1986). 38. Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463-5467 (1977). 39. Devereux, J., Haeberil, P. & Smithies, O. Nucleic Acid Res. 12, 387-395 (1984). 40. Staden, R. Nucleic Acid Res. 10,2951-2961 (1982). 41. Kunkel, T. A. Proc. natn. Acad. Sci. U.S.A. 82, 488-492 (1985). 42. Wigler, M. et al. Cell 16, 777-785 (1979). 43. Gorman, C. M., Moffat, L. F. & Howard, B. H. Molec. cell. Biol. 2, 1044-1051 (1982). 44. Deans, R. J. et al. Proc. natn. Acad. Sci. USA 81, 1292-1296 (1984). 45. Southern, E. M. / molec. Biol. 98, 503-517 (1975). 46. Chirgwin, J. M., Przybyla, A. F., McDonald, R. J. & Rutter, W. F. Biochemistry 18,5294-5299 (1980).
Author information
Affiliations
Rights and permissions
About this article
Cite this article
Giguere, V., Ong, E., Segui, P. et al. Identification of a receptor for the morphogen retinoic acid. Nature 330, 624–629 (1987). https://doi.org/10.1038/330624a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/330624a0
Further reading
-
A master of all trades – linking retinoids to different signalling pathways through the multi-purpose receptor STRA6
Cell Death Discovery (2021)
-
The role of the retinoids in schizophrenia: genomic and clinical perspectives
Molecular Psychiatry (2020)
-
The reduced susceptibility of mouse keratinocytes to retinoic acid may be involved in the keratinization of oral and esophageal mucosal epithelium
Histochemistry and Cell Biology (2020)
-
Vitamin A: its many roles—from vision and synaptic plasticity to infant mortality
Journal of Comparative Physiology A (2020)
-
A Novel Gene Bombyx mori Carotenoid Oxygenases and Retinal Isomerase (BmCORI) Related to β-Carotene Depletion
Biochemical Genetics (2020)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
