Abstract
A putative growth hormone receptor from rabbit liver and the growth hormone binding protein from rabbit serum have the same ammo-terminal amino-acid sequence, indicating that the binding protein corresponds to the extracellular hormone-binding domain of the liver receptor. The complete amino-acid sequences derived from complementary DNA clones encoding the putative human and rabbit growth hormone receptors are not similar to other known proteins, demonstrating a new class of transmembrane receptors.
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References
1. Nilsson, A. et al. Science 233, 571–574 (1986). 2. Lindahl, A., Isgaard, J., Nilsson, A. & Isaksson, O. G. P. Endocrinology 118, 1843–1848 (1986). 3. Salmon, W. D. Jr & Daughaday, W. H. J. Lab. din. Invest. 49, 825–836 (1957). 4. Hughes, J. P. & Friesen, H. G. A Rev. Physiol. 47, 469–482 (1985). 5. Isaksson, O. G. P., Eden, S. & Jansson, J.-O. A. Rev. Physiol. 47, 483–499 (1985). 6. Zezulak, K. M. & Green, H. Science 233, 551–553 (1986). 7. Rechler, M. M., Nissley, S. P. & Roth, J. N. Engl. J. Med. 316, 941–942 (1987). 8. Waters, M. J. & Friesen, H. G. /. biol. Chem. 254, 6815–6825 (1979). 9. Tsushima, T. et al. FEBS Lett. 147, 49–53 (1982). 10. Haeuptle, M.-T., Aubert, M. L., Djiane, J. & Kraehenbuhl, J.-P. J. biol. Chem. 258,305–314(1983). 11. Donner, D. B. / biol. Chem. 258, 2736–2743 (1983). 12. Carter-Su, C., Schwartz, J. & Kikuchi, G. J. biol. Chem. 259, 1099–1104 (1984). 13. Hughes, J. P., Simpson, J. S. A. & Friesen, H. G. Endocrinology 112, 1980–1985 (1983). 14. Asakawa, I. K. et al. Biochem. J. 238, 379–386 (1986). 15. Ymer, S. I. & Herington, A. C. Molec. cell. Endocrinol. 41, 153–161 (1985). 16. Baumann, G., Stolar, M. W., Amburn, K., Barsano, C. P. & DeVries, B. C. J. din. Endocr. Metab. 62, 134–141 (1986). 17. Herington, A. C., Ymer, S. I. & Stevenson, J. L. J. din. Invest. 77, 1817–1823 (1986). 18. Barnard, R. & Waters, M. J. Biochem. J. 237, 885–892 (1986). 19. Barnard, R., Bundesen, P. G., Rylatt, D. B. & Waters, M. J. Endocrinology 115, 1805–1813(1984). 20. Barnard, R., Bundesen, P. G., Rylatt, D. B. & Waters, M. J. Biochem. J. 231, 459–468(1985). 21. Schlesinger, D. H., Goldstein, G. & Niall, H. D. Biochemistry 14, 2214–2218 (1975). 22. Goldknopf, I. L. & Busch, H. Proc. najn. Acad. Sci. U.S.A. 74, 864–868 (1977). 23. Siegelman, M. et al. Science 231, 823–829 (1986). 24. Yarden, Y. et al. Nature 323, 226–232 (1986). 25. Baxter, R. C. Endocrinology 117, 650–655 (1985). 26. Gorin, E. & Goodman, H. M. Endocrinology 116, 1796–1805 (1985). 27. Littman, D. R., Thomas, Y., Maddon, P. J., Chess, L. & Axel, R. Cell 40, 237–246 (1985). 28. Kuhn, L. C., Barbosa, J. A., Kamarck, M. E. & Ruddle, F. H. Molec. Biol. Med. 1, 335–352 (1983). 29. Huynh, T. V., Young, R. A. & Davis, R. W. DNA Cloning vol. I (ed. Glover, D.) 49–78 (IRL, Oxford, 1985). 30. Peralta, E. G. et al. Science 236, 600–605 (1987). 31. Adelman, J. P., Mason, A. J., Hayflick, J. S. & Seeburg, P. H. Proc. natn. Acad. Sci. U.S.A. 83, 179–183 (1986). 32. Coussens, L. et al. Nature 320, 277–280 (1986). 33. Perlman, D. & Halvorson, H. O. J. molec. Biol. 167, 309 (1983). 34. Kozak, M. Nucleic Acids Res. 12, 857–872 (1984). 35. Marshall, R. D. A. Rev. Biochem. 41, 673–702 (1972). 36. Russell, D. W. et al. Cell 37, 577–585 (1984). 37. Yarden, Y. et al. Nature 323, 226–232 (1986). 38. Ullrich, A. et al. Nature 309, 418–425 (1984). 39. Yamamoto, T. et al. Cell 39, 27–38 (1984). 40. Cook, J. J., Haynes, K. M., Barnard, R., Waters, M. J. & Werther, G. A. Proc. Endocrine Soc. U.S.A. 69, 618 (1987). 41. McKusick, V. A. Mendelian Inheritance in Man, 6th edn, 895–896 (Johns Hopkins University Press, Baltimore, 1983). 42. Merimee, T. J., Zapf, J., Hewlett, B. & Cavalli-Sforza, L. L. N. Engl. J. Med. 316, 906–911 (1987). 43. Eshet, R., Laron, Z., Pertzelan, A., Arnon, R. & Dintzman, M. Israel J. med. Sci. 20, 8–11 (1984). 44. Daughaday, W. H. & Trivedi, B. Proc. natn. Acad. Sci. U.S.A. 84, 4636–4640 (1987). 45. Baumann, G, Shaw, M. A. & Winter, R. J. din. Res. 35, 582A (1987). 46. Maniatis, T., Frisch, E. F. & Sambrook, J. Molecular Cloning. A Laboratory Manual (Cold Spring Harbor, New York, 1982). 47. Cathala, G. et al. DNA 2, 329–335 (1983). 48. Gubler, U. & Hoffman, B. J. Gene 25, 263–269 (1983). 49. Wood, W. I. et al. Nature*3l2, 330–337 (1984). 50. Lathe, R. / molec. Biol. 183, 1–12 (1985). 51. Wood, W. I., Gitschier, J., Lasky, L. A. & Lawn, R. M. Proc. natn. Acad. Sci. U.S.A. 82, 1585–1588 (1985). 52. Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977). 53. Kyte, J. & Doolittle, R. F. J. molec. Biol. 157, 105–132 (1982). 54. Gluzman, Y. Cell 23, 175–182 (1981). 55. German, C. DNA Cloning Vol. II (ed. Glover, D.) 143–190 (IRL, Oxford, 1985). 56. Eaton, D. L. et al. Biochemistry 25, 8343–8347 (1986).
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Leung, D., Spencer, S., Cachianes, G. et al. Growth hormone receptor and serum binding protein: purification, cloning and expression. Nature 330, 537–543 (1987). https://doi.org/10.1038/330537a0
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DOI: https://doi.org/10.1038/330537a0
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