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A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukaemia

Nature volume 330, pages 386–388 (1987)Cite this article

Abstract

The leukaemic cells of more than 90% of chronic myelogenous leukaemia (CML) patients and of 10% of acute lymphocytic leukaemia (ALL) patients carry the t(9:22) (q34:qll) translocation which generates the Philadelphia chromosome (Ph1). In CML the abl gene is translocated from chromosome 9 to the centre of the bcr gene on chromosome 22 and this results in production of chimaeric bcr-abl RNA translated into a protein of relative molecular mass (Mr) 210,000 (210K). Our data indicate that in ALL abl is translocated into the 5' region of the bcr gene. The consequence of this is the expression of a fused transcript in which the first exon of bcr is linked to the second abl exon. This transcript encodes a 190K protein kinase.

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Author notes

  1. R. P. Gale and O. Dreazen: Department of Medicine, University of California, Los Angeles, California 90024, USA

  2. S. D. Smith: Department of Pediatrics, Children's Hospital at Stanford, Palo Alto, California 94304, USA

  3. C. M. Croce: The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA

  4. E. Canaani: To whom correspondence should be addressed.

Authors and Affiliations

  1. Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel

    E. Fainstein, C. Marcelle, A. Rosner, E. Canaani, R. P. Gale, O. Dreazen, S. D. Smith & C. M. Croce

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  1. E. Fainstein
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  2. C. Marcelle
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  3. A. Rosner
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  4. E. Canaani
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  5. R. P. Gale
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  6. O. Dreazen
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  7. S. D. Smith
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  8. C. M. Croce
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Fainstein, E., Marcelle, C., Rosner, A. et al. A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukaemia. Nature 330, 386–388 (1987). https://doi.org/10.1038/330386a0

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