Table 3 Studies using alternative gene therapy in various disease models

From: Bacteria in gene therapy: bactofection versus alternative gene therapy

Vector Target gene Disease Model Result Reference
B. longum Endostatin Liver cancer Mus musculus Positive Fu et al, 20058
S. typhimurium Cytosine deaminase Refractory cancer Homo sapiens Positive Nemunaitis et al, 200320
B. adolescentis Endostatin Liver cancer Mus musculus Positive Li et al, 200339
C. beijerinckii Cytosine deaminase Mammary carcinoma EMT6 murine carcinoma cells Positive Fox et al, 199625
S. typhimurium IL-2 Adenocarcinoma Mus musculus Positive Saltzman et al, 199640
E. coli VEGF Ischemia Mus musculus Positive Celec et al, 200513
C. sporogenes Cytosine deaminase Solid tumor Mus musculus Positive Liu et al, 200227