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Muscle-derived stem cells

Gene Therapy volume 9, pages 642–647 (2002)Cite this article

Abstract

The existence of cells with stem cell-like abilities derived from various tissues can now be extended to include the skeletal muscle compartment. Although researchers have focused on the utilization of these cells with regard to their myogenic capacity, initially exploring more efficient cellular therapy treatments for muscular dystrophy, it is becoming increasingly apparent that such cells may one day be used in the treatment of non-myogenic disorders. Evidence regarding the existence and differentiation capacity of muscle-derived stem cells is discussed, along with current theories regarding their proposed position within the myogenic hierarchy.

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Acknowledgements

This work was supported in part by grants to Dr Huard from the National Institutes of Health (1P60 AR44811-01, 1PO1 AR45925-01), the Pittsburgh Tissue Engineering Initiative (PTEI), the William F and Jean W Donaldson Chair at Children's Hospital of Pittsburgh, the Muscular Dystrophy Association (USA), the Parent Project (USA), and the Orris C Hirtzel and Beatrice Dewey Hirtzel Memorial Foundation.

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  1. Bioengineering Department, Growth and Development Laboratory, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA

    R J Jankowski, B M Deasy & J Huard

  2. Department of Orthopaedic Surgery, Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, PA, USA

    J Huard

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  1. R J Jankowski
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  2. B M Deasy
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  3. J Huard
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Jankowski, R., Deasy, B. & Huard, J. Muscle-derived stem cells. Gene Ther 9, 642–647 (2002). https://doi.org/10.1038/sj.gt.3301719

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