Figure 6 | Gene Therapy

Figure 6

From: Increasing endothelial cell specific expression by the use of heterologous hypoxic and cytokine-inducible enhancers

Figure 6

Effect of a cytokine-inducible enhancer on KDR promoter activity after retroviral delivery. The fold enhancement was calculated by dividing the expression levels after stimulation by baseline levels of expression. sEND cells were infected with NFkB-SKL retrovirus. The fold enhancement after stimulation with TNF-α (10 ng/ml, 16 h) is significant (*P < 0.05), whereas the slight increase in sEND cells infected with SKL is not. (The mean of five independent experiments is shown.) PMBE cells were infected with the HRE-NFkB-SKL retrovirus and stimulated with TNF-α (10 ng/ml) or/and hypoxia (0.1% O2) for 6 h and 16 h. The values show the mean of five independent experiments. (# has been measured only twice; the mean is shown.)

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