Abstract
Multiple endocrine neoplasis type 2A (MEN2A) is one of several kinds of cancers that appear to be inherited in an autosomally dominant fashion. We have assigned the MEN2A locus to chromosome 10 by linkage with a new DNA marker (D10S5). The linkage led us to investigate other chromosome 10 markers and demonstrate linkage between the disease locus and the interstitial retinol-binding protein (IRBP) gene1. The D10S5 locus was sublocalized to 10q21.1 by hybridization in situ2 and the IRBP gene to p11.2→ q11.2 with a secondary site at q24→q251 The linkages were established using 292 members of five families, three different restriction fragment length polymorphisms (RFLPs) at D10S5 and two RFLPs recognized by the IRBP probe. The recombination frequencies from pairwise linkage analysis between the disease and two marker loci DIGS5 and IRBP were 0.19 and 0.11, with maximum lod scores of 3.6 and 8.0 respectively. Ordering of the three loci by multipoint analysis placed the IRBP gene approximately midway between the disease and D10S5 loci.
This is a preview of subscription content
Access options
Subscribe to Journal
Get full journal access for 1 year
204,58 €
only 4,01 € per issue
Tax calculation will be finalised during checkout.
Buy article
Get time limited or full article access on ReadCube.
$32.00
All prices are NET prices.
References
1. Liou, G. I. et al. Nucleic Acids Res. 15, 3196 (1987). 2. McDermid, H. et al. Nucleic Acids Res. (in the press). 3. Simpson, N. E. & Kidd, K. K. Henry Ford Hosp. med. J. (in the press). 4. Babu, V. R., Van Dyke, D. L., & Jackson, C. E. Proc. natn. Acad. Sci. U.S.A. 81, 2525–2528 (1984). 5. Babu, V. R., VanDyke, D. L., Flejter, W. C., Jackson, C. E. Am. J. med. Genet, (in the press). 6. Goodfellow, P. J. et al. Am. J. hum. Genet. 37, 890–897 (1985). 7. Fairer, L. A. et al. Cancer genet. Cytogenet. (in the press). 8. Partington, M. W., Ghent, W. R., Sears, E. V. P., & Simpson, N. E. Can. med. Ass. J. 124, 403–410 (1981). 9. Birr, A. R., Hogg, G. R., & Dube, W. J. Arch. Dermatol. 113, 1674–1677 (1977). 10. Duncan, A. M. V. & Greenberg, C. R. Cancer Genet. Cytogenet. 22, 109–112 (1986). 11. Jackson, C. E. et al. Ann. intern. Med. 78, 845–852 (1973). 12. Hamilton, B. P., Landsberg L, & Levine, R. J. Am. J. Med. 65, 1027–1032 (1978). 13. Kruger, S. D. et al. Hum. Hered. 36, 6–11 (1986). 14. Keiser, H. R. Beaven, M. A., Doppman, J., Wells, Jr, S. & Buja, L. M. Ann. Intern. Med. 78, 561–579 (1973). 15. Ott, J. in Analysis of Human Genetic Linkage (Johns Hopkins University Press, Baltimore, 1985). 16. Ott, J. Am. J. hum. Genet. 26, 588–597 (1974). 17. Morton, N. E. Am. J. hum. Genet. 7, 277–318 (1955). 18. Lathrop, G. M. et al Proc. natn. Acad. Sci. U.S.A. 81, 3443–3446 (1984).
Author information
Affiliations
Rights and permissions
About this article
Cite this article
Simpson, N., Kidd, K., Goodfellow, P. et al. Assignment of multiple endocrine neoplasia type 2A to chromosome 10 by linkage. Nature 328, 528–530 (1987). https://doi.org/10.1038/328528a0
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/328528a0
Further reading
-
The importance of the RET gene in thyroid cancer and therapeutic implications
Nature Reviews Endocrinology (2021)
-
Genetic basis of Hirschsprung’s disease
Pediatric Surgery International (2009)
-
Multiple endocrine neoplasia syndromes, children, Hirschsprung’s disease and RET
Pediatric Surgery International (2008)
-
Prophylaktische Chirurgie der Schilddrüse
Der Chirurg (2006)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
