Abstract
Retrovirus-mediated gene transfer was used to mark cell lineages in vivo in the postnatal rat retina. Labelled clones contained up to three different cell types: three types of neurons or two types of neurons and a Müller glial cell. This indicates that a single retinal progenitor can generate remarkably diverse cell types near the end of development.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
204,58 € per year
only 4,01 € per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
1. Jacobson, M. Developmental Neurobiology 2nd edn, 27–55 (Plenum, New York, 1982). 2. Price, J., Turner, D. & Cepko, C. Proc. natn. Acad. Sci. U.S.A. 84, 154–160 (1987). 3. Sanes, J. R., Rubenstein, J. L. R. & Nicolas, J. EMBO J. 5, 3133–3142 (1986). 4. Soriano, P. & Jaenisch, R. Cell 46, 19–29 (1986). 5. Lemischka, I. R., Rulet, D. H. & Mulligan, R. C. Cell 45, 917–927 (1986). 6. Kimmel, C. B. & Warga, R. M. Science 231, 365–368 (1986). 7. Mintz, B. & Sanyal, S. Genetics 64, suppl. 43–44 (1970). 8. Moody, S. A. & Jacobson, M. J. Neurosci. 3, 1670–1682 (1983). 9. Le Douarin, N. M. Science 231, 1515–1522 (1986). 10. Raff, M. C., Miller, R. H. & Noble, M. Nature 303, 390–396 (1983). 11. Sidman, R. L. The Structure of the Eye 487–506 (Academic, New York, 1961). 12. Denham, S. J. Embryol. exp. Morph. 18, 53–66 (1966). 13. Young, R. W. Anat. Rec. 212, 199–205 (1985). 14. Carter Dawson, L. D. & LaVail, M. M. J. comp. Neurol. 188, 263–272 (1979). 15. Blanks, J. C. & Bok, D. J. comp. Neurol. 174, 317–328 (1977). 16. Rodieck, R. W. The Vertebrate Retina 338–368 (Freeman, San Francisco, 1973). 17. Raviola, E. & Gilula, N. B. Proc. natn. Acad. Sci. U.S.A. 70, 1677–1681 (1973). 18. Lam, K., Sefton, A. J. & Bennett, M. R. Devl Brain Res. 3, 487–491 (1982). 19. Young, R. W. J. comp. Neurol. 229, 362–373 (1984). 20. Varmus, H. E., Padgett, T., Haesley, S., Simon, G. & Bishop, J. M. Cell 11, 307–319 (1977). 21. Keller, G., Paige, C., Gilboa, E. & Wagner, E. F. Nature 318, 149–154 (1985). 22. Stewart, C. L., Vanek, M. & Wagner, E. F. EMBO J. 4, 3701–3709 (1985). 23. Eglitis, M. A., Kantoff, P., Gilboa, E. & Anderson, W. F. Science 230, 1395–1398 (1985). 24. Huszar, D. et al. Proc. natn. Acad. Sci. U.S.A. 82, 8587–8591 (1985). 25. Williams, D. A., Orkin, S. H. & Mulligan, R. C. Proc. natn. Acad. Sci. U.S.A. 83, 2566–2570 (1986). 26. Robertson, E., Bradley, A. & Kuehn, M. Nature 323, 445–448 (1986). 27. Kyritsis, A., Tsokos, M., Triche, T. & Chader, G. Nature 307, 471–473 (1984). 28. Jiang, Q., Lim, R. & Blodi, F. C. Expl Eye Res. 39, 207–215 (1984). 29. Canton, M. D., Hinton, D., Gray, D., Phillips, R. A. & Gallic, B. B. L. Invest. Ophthalmol. Vis. Sci. 25, suppl. 259(1985). 30. Sulston, J. E. & Horvitz, H. R. Devl Biol. 56, 110–156 (1977). 31. Ready, D. F., Hanson, T. E. & Benzer, S. Devl Biol. 53, 217–240 (1976). 32. Tomlinson, A. & Ready, D. F. Devl Biol. 120, 366–374 (1987). 33. Hafen, E., Basler, K., Edstroem, J. & Rubin, G. M. Science 236, 55–63 (1987). 34. Banerjee, U., Renfranz, P., Pollack, J. & Benzer, S. Cell 49, 281–291 (1987). 35. Coulombre, J. L. & Coulombre, A. J. Devl Biol. 12, 79–92 (1965). 36. Moscona, A. A., Brown, M., Degenstein, L., Fox, L. & Son, B. M. Proc. natn. Acad. Sci. U.S.A. 80, 7239–7243 (1983). 37. Levitt, P., Cooper, M. L. & Rakic, P. /. Neurosci. 1, 27–39 (1981). 38. Hubel, D. H. & Wiesel, T. N. Proc. R. Soc. B198, 1–59 (1977).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Turner, D., Cepko, C. A common progenitor for neurons and glia persists in rat retina late in development. Nature 328, 131–136 (1987). https://doi.org/10.1038/328131a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/328131a0
