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Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells

Nature volume 328, pages 38–43 (1987)Cite this article

Abstract

Biochemical and biophysical studies on Aplysia sensory neurons indicate that inhibitory responses to the molluscan peptide FMRFamide are mediated by lipoxygenase metabolites of arachidonic acid. These compounds are a new class of second messengers in neurons.

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Author notes

  1. F. Belardetti

    Present address: Department of Pharmacology, University of Texas, Health Science Center, Dallas, Texas, 75235, USA

Authors and Affiliations

  1. Howard Hughes Medical Institute and Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, New York, 10032, USA

    N. Dale, S. A. Siegelbaum, E. R. Kandel, J. H. Schwartz & F. Belardetti

  2. Departments of Pharmacology, Columbia University, College of Physicians and Surgeons, New York, New York, 10032, USA

    D. Piomelli, A. Volterra & S. A. Siegelbaum

  3. Departments of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, New York, 10032, USA

    E. R. Kandel

  4. Departments of Physiology, Columbia University, College of Physicians and Surgeons, New York, New York, 10032, USA

    J. H. Schwartz

  5. Departments of Neurology, Columbia University, College of Physicians and Surgeons, New York, New York, 10032, USA

    J. H. Schwartz

Authors
  1. D. Piomelli
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  3. N. Dale
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  5. E. R. Kandel
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  6. J. H. Schwartz
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  7. F. Belardetti
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Piomelli, D., Volterra, A., Dale, N. et al. Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells. Nature 328, 38–43 (1987). https://doi.org/10.1038/328038a0

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