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Prevalence of ras gene mutations in human colorectal cancers

Naturevolume 327pages293297 (1987) | Download Citation

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Abstract

The Department of Medical Biochemistry and t Department of Organic Chemistry, State University of Leiden, Sylvius Laboratories, The Netherlands * The Oncology Center and t Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.

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Author notes

  1. Jacques H. van Boom: Department of Organic Chemistry, State University of Leiden, Sylvius Laboratories, The Netherlands

  2. Eric R. Fearon and Bert Vogelstein: The Oncology Center and

  3. Stanley R. Hamilton: Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA

  4. Bert Vogelstein: To whom correspondence should be addressed.

Affiliations

  1. The Department of Medical Biochemistry and

    • Johannes L. Bos
    • , Eric R. Fearon
    • , Stanley R. Hamilton
    • , Matty Verlaan–de Vries
    • , Jacques H. van Boom
    • , Alex J. van der Eb
    •  & Bert Vogelstein

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https://doi.org/10.1038/327293a0

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