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Prevalence of ras gene mutations in human colorectal cancers


The Department of Medical Biochemistry and t Department of Organic Chemistry, State University of Leiden, Sylvius Laboratories, The Netherlands * The Oncology Center and t Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.

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  1. 1

    1. Land, H., Parada, L. F. & Weinberg, R. A. Science 222, 771–778 (1983). 2. Cooper, G. M. Science 218, 801–806 (1982). 3. Barbacid, M. Trends Genet. 2, 188–192 (1986). 4. Land, H., Parada, L. F. & Weinberg, R. A. Nature 304, 596–602 (1983). 5. Ruley, H. E. Nature 304, 602–606 (1983). 6. Newbold, R. F. & Overrell, R. W. Nature 304, 648–651 (1983). 7. Fujita, J. et al. Proc. natn. Acad. Sci. U.S.A. 82, 3849–3853 (1985). 8. Kraus, M. H., Yuasa, Y. & Aaronson, S. A. Proc. natn. Acad. Sci. U.S.A. 81,5384–5388 (1984). 9. Sakamoto, H. et al. Proc. natn. Acad. Sci. U.S.A. 83, 3997–4001 (1986). 10. Capon, D. J. et al. Nature 304, 507–513 (1983). 11. Shimizu, K. et al. Nature 304, 497–500 (1983). 12. Saiki, R. et al. Science 230, 1350–1353 (1985). 13. Mullis, K. B. & Faloona, F. A. Meth. Enzym. (in the press). 14. Verlaan–de Vries, M. et al. Gene 50, 313–320 (1986). 15. Fasano, O. et al. Proc. natn. Acad. Sci. U.S.A. 81, 4008–4012 (1984). 16. Bos, J. L. et al. Nature 315, 726–730 (1985). 17. Goelz, S. E., Hamilton, S. R. & Vogelstein, B. Biochem. biophys. Res. Commun. 130,118–125 (1985). 18. Sugarbaker, P. H., Gunderson, L. L. & Wittes, R. E. in Cancer. Principles and Practice in Oncology (eds DeVita, V. T., Hellman, S. & Rosenberg, S. A.) 795–836 (Lippincott, Philadelphia, 1985). 19. Winter, E., Yamamoto, F., Almoguera, C. & Perucho, M. Proc. natn. Acad. Sci. U.S.A. 82, 7575–7579 (1985). 20. Bos, J. L. et al. Nucleic Acids Res. 14, 1209–1217 (1986). 21. Yuasa, Y. et al. Jap. J. Cancer Res. 27, 901–907 (1986). 22. Yuasa, Y., Reddy, E. P., Rhim, J. S., Tronick, S. R. & Aaronson, S. A. Jap. J. Cancer Res. 77,639–647 (1986). 23. Gilbertson, V. A. Cancer 34, 936–939 (1974). 24. Eide, T. J. Int. J. Cancer 38, 173–176 (1986). 25. Muto, T., Bussey, H. J. R. & Morson, B. C. Cancer 36, 2251–2270 (1975). 26. Shinya, H. & Wolff, W. I. Ann. Surg. 190, 679–683 (1979). 27. Quintanilla, M., Brown, K., Ramsden, M. & Balmain, A. Nature 322, 78–80 (1986). 28. Reynolds, S. H. et al. Proc. natn. Acad. Sci. U.S.A. 83, 33–37 (1986). 29. Bos, J. L. et al. Nucleic Acids Res. 12, 9155–9163 (1984). 30. Fearon, E. R., Feinberg, A. P., Hamilton, S. R. & Vogelstein, B. Nature 318, 377–380 (1985).

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Bos, J., Fearon, E., Hamilton, S. et al. Prevalence of ras gene mutations in human colorectal cancers. Nature 327, 293–297 (1987).

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