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Prevalence of ras gene mutations in human colorectal cancers

Abstract

The Department of Medical Biochemistry and t Department of Organic Chemistry, State University of Leiden, Sylvius Laboratories, The Netherlands * The Oncology Center and t Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.

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Bos, J., Fearon, E., Hamilton, S. et al. Prevalence of ras gene mutations in human colorectal cancers. Nature 327, 293–297 (1987). https://doi.org/10.1038/327293a0

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