Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Atrial natriuretic peptide inhibits angiotensin-stimulated proximal tubular sodium and water reabsorption

Nature volume 326, pages 697–698 (1987)Cite this article

Abstract

The discovery that atrial extracts have potent diuretic and natriuretic properties1 revealed a possible endocrine function of the heart in the regulation of extracellular fluid volume. Since that first report intense research activity has been directed towards determining the mechanism of action of the active atrial natriuretic polypeptides (ANP) found in these extracts. Despite these efforts it remains controversial whether the renal actions of ANP are exerted solely on the process of glomerular filtration or involve additional direct actions on tubular transport. We have investigated the possibility that atrial natriuretic polypeptides may induce natriuresis by suppression of proximal tubular sodium and water reabsorption. Using shrinking split-drop micropuncture combined with simultaneous capillary perfusion in anaesthetized rats we report that 20 nanomolar α-rANP1–23 (the main component of ANP in rat plasma) added to the peritubular fluid had no direct effect on proximal fluid uptake whereas picomolar angiotensin II had a marked stimulatory action as reported2. The stimulatory effect of angiotensin II on fluid reabsorption was inhibited by peritubular ANP at physiological concentrations and abolished by higher concentrations of ANP. Thus at physiological concentrations3,4 ANP acts within the kidney to decrease proximal reabsorption by inhibition of angiotensin-stimulated sodium and water transport.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. DeBold, A. J., Borenstein, H. B., Veress, A. T. & Sonnenberg, H. Life Sci. 28, 89–94 (1981).

    Article  CAS  Google Scholar 

  2. Harris, P. J. & Young, J. A. Pflügers Arch. ges. Physiol. 367, 295–297 (1977).

    Article  CAS  Google Scholar 

  3. Tanaka, I., Misono, K. S. & Ingami, T. Biochem. biophys. Res. Commun. 124, 663–668 (1984).

    Article  CAS  Google Scholar 

  4. Miyata, A., Kangawa, K., Toshimori, T., Hatoh, T. & Matsuo, H. Biochem. biophys. Res. Commun. 129, 248–255 (1985).

    Article  CAS  Google Scholar 

  5. Cogan, M. G. Am. J. Physiol. 250, F710–F714 (1986).

    CAS  PubMed  Google Scholar 

  6. Burnett, J. C. Jrh, Granger, J. P. & Opgenorth, T. J. Am. J. Physiol. 247, F863–F866 (1984).

    CAS  PubMed  Google Scholar 

  7. Burnett, J. C. Jr, Opgenorth, T. J. & Granger, J. P. Kidney Int. 30, 16–19 (1986).

    Article  CAS  Google Scholar 

  8. Gellai, M., DeWolf, R. E., Kinter, L. B. & Beuwkes, R. III Circulation Res. 59, 56–62 (1986).

    Article  Google Scholar 

  9. Baum, M. & Toto, R. D. Am. J. Physiol. 250, F66–F69 (1986).

    CAS  PubMed  Google Scholar 

  10. Kondo, Y., Imai, M., Kangawa, K. & Matsuo, H. Pflügers Arch. ges. Physiol. 406, 273–278 (1986).

    Article  CAS  Google Scholar 

  11. Kleinert, H. D. et al. Hypertension 6 (suppl. 1), 1143–1147 (1984).

    Article  Google Scholar 

  12. Di Nicolantonio, R., Stevens, J., Weaver, D. & Morgan, T. O. Clin. exp. Pharmac. Physiol. 13, 311–315 (1986).

    Article  CAS  Google Scholar 

  13. Atarashi, K., Mulrow, P. J., Franco-Saenz, R., Snajdar, R. & Rapp, J. Science 224, 992–994 (1984).

    Article  ADS  CAS  Google Scholar 

  14. Schuster, V. L., Kokko, J. P. & Jacobson, H. R. J. clin. Invest. 73, 507–515 (1984).

    Article  CAS  Google Scholar 

  15. Gyory, A. Z., Lingard, J. M., & Young, J. A. Pflügers Arch. ges. Physiol. 348, 205–210 (1974).

    Article  CAS  Google Scholar 

  16. Harris, P. J., Cullinan, M. & Thomas, D. Pflügers Arch. ges. Physiol. (in the press).

  17. Spinelli, F., Kamber, B. & Schnell, C. J. Hypertension 4 (suppl. 2), S25–S29 (1986).

    CAS  Google Scholar 

  18. Kurtz, A., Bruna, R. D., Pfeilschifter, J. & Bauer, C. J. Hypertension 4 (suppl. 2) S57–S60 (1986).

    Article  CAS  Google Scholar 

  19. Huang, C-L., Ives, H. E. & Cogan, M. G. Kidney Int. 29, 384 (1986).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, University of Melbourne, Parkville, Victoria, 3052, Australia

    Peter J. Harris, David Thomas & Trefor O. Morgan

Authors
  1. Peter J. Harris
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David Thomas
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Trefor O. Morgan
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Harris, P., Thomas, D. & Morgan, T. Atrial natriuretic peptide inhibits angiotensin-stimulated proximal tubular sodium and water reabsorption. Nature 326, 697–698 (1987). https://doi.org/10.1038/326697a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/326697a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing