Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor

Nature volume 326, pages 353–358 (1987)Cite this article

Abstract

We show that nerve growth factor (NGF) synthesis in developing skin begins with sensory innervation and that sensory neurons do not express NGF receptors until their fibres reach their cutaneous targets. Both cutaneous epithelium and mesenchyme synthesize NGF, the concentration of messenger RNAfor NGF being higher in the more densely innervated epithelium.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

References

  1. Oppenheim, R. W. in Studies in Developmental Biology (ed. Cowan, W. M.) 74–133 (Oxford University Press, Oxford, 1981).

    Google Scholar 

  2. Hamburger, V. & Levi-Montalcini, R. J. exp. Zool. 162, 133–160 (1949).

    Article  Google Scholar 

  3. Levi-Montalcini, R. & Angeletti, P. U. Physiol. Rev. 48, 534–569 (1968).

    Article  CAS  Google Scholar 

  4. Thoenen, H. & Barde, Y.-A. Physiol. Rev. 60, 1284–1335 (1980).

    Article  CAS  Google Scholar 

  5. Davies, A. M. & Lindsay, R. M. Devl Biol. 111, 62–72 (1985).

    Article  CAS  Google Scholar 

  6. Rohrer, H. & Barde, Y.-A. Devl Biol. 89, 309–315 (1982).

    Article  CAS  Google Scholar 

  7. Hendry, I. A. & Campbell, J. J. Neurocytol. 5, 351–360 (1976).

    Article  CAS  Google Scholar 

  8. Hamburger, V., Brunso-Bechtold, J. K. & Yip, J. W. J. Neurosci. 1, 60–71 (1981).

    Article  CAS  Google Scholar 

  9. Gorin, P. D. & Johnston, E. M. Proc. natn. Acad. Sci. U.S.A. 76, 5382–5386 (1979).

    Article  ADS  CAS  Google Scholar 

  10. Heumann, R., Korsching, S., Scott, J. & Thoenen, H. EMBO J. 3, 3183–3189 (1984).

    Article  CAS  Google Scholar 

  11. Shelton, D. L. & Reichardt, L. F. Proc. natn. Acad. Sci. U.S.A. 81, 7951–7955 (1984).

    Article  ADS  CAS  Google Scholar 

  12. Hendry, I. A., Stoeckel, K., Thoenen, H. & Iversen, L. L. Brain Res. 68, 103–121 (1974).

    Article  CAS  Google Scholar 

  13. Stoeckel, K., Schwab, M. & Thoenen, H. Brain Res. 89, 1–14 (1974).

    Article  Google Scholar 

  14. Angeletti, R. H. & Bradshaw, R. A. Proc. natn. Acad. Sci. U.S.A. 68, 2417–2420 (1971).

    Article  ADS  CAS  Google Scholar 

  15. Scott, J. et al. Nature 302, 538–540 (1983).

    Article  ADS  CAS  Google Scholar 

  16. Ullrich, A., Gray, A., Berman, C. & Dull, T. J. Nature 303, 821–825 (1983).

    Article  ADS  CAS  Google Scholar 

  17. Darling, T. L. J. et al. Cold Spring Harb. Symp. quant. Biol. 48, 427–434 (1983).

    Article  CAS  Google Scholar 

  18. Menescini-Chen, M. G., Chen, J. S. & Levi-Montalcini, R. Archs ital. Biol. 116, 53–84 (1978).

    Google Scholar 

  19. Letourneau, P. C. Devl Biol. 66, 183–196 (1978).

    Article  CAS  Google Scholar 

  20. Gundersen, R. W. & Barrett, J. N. Science 206, 1079–1080 (1979).

    Article  ADS  CAS  Google Scholar 

  21. Levi-Montalcini, R. Prog. Brain Res. 45, 235–258 (1976).

    Article  CAS  Google Scholar 

  22. Renehan, W. E. & Munger, B. L. J. comp. Neurol. 246, 129–145 (1986).

    Article  CAS  Google Scholar 

  23. Iggo, A. Br. med. Bull. 33, 97–102 (1977).

    Article  CAS  Google Scholar 

  24. Iggo, A. & Andres, K. H. A. Rev. Neurosci. 5, 1–31 (1982).

    Article  CAS  Google Scholar 

  25. Davies, A. M. & Lumsden, A. G. S. J. comp. Neurol. 223, 124–137 (1984).

    Article  CAS  Google Scholar 

  26. Davies, A. M. & Lumsden, A. G. S. J. comp. Neurol. 253, 13–24 (1986).

    Article  CAS  Google Scholar 

  27. Korsching, S. & Thoenen, H. Proc. natn. Acad. Sci. U.S.A. 80, 3513–3516 (1983).

    Article  ADS  CAS  Google Scholar 

  28. Bandtlow, C., Heumann, R., Schwab, M. & Thoenen, H. EMBO J. (in the press).

  29. Rush, R. A. Nature 312, 364–367 (1984).

    Article  ADS  CAS  Google Scholar 

  30. Finn, P. J., Ferguson, I. A., Renton, F. J. & Rush, R. A. J. Neurocytol. 15, 169–176 (1986).

    Article  CAS  Google Scholar 

  31. Lumsden, A. G. S. & Davies, A. M. Nature 306, 786–788 (1983).

    Article  ADS  CAS  Google Scholar 

  32. Lumsden, A. G. S. & Davies, A. M. Nature 323, 538–539 (1986).

    Article  ADS  CAS  Google Scholar 

  33. Lowry, O. H., Rosenbrough, N. J., Farr, A. L. & Randall, R. J. J. biol. Chem. 193, 265–275 (1951).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anatomy, St George's Hospital Medical School, Cranmer Terrace, Tooting, London, SW17 ORE, UK

    Alun M. Davies

  2. Department of Neurochemistry, Max-Planck-Institute for Psychiatry, 8033 Planegg-Martinsried, Munchen, FRG

    Christine Bandtlow, Rolf Heumann, Sigrun Korsching, Hermann Rohrer & Hans Thoenen

Authors
  1. Alun M. Davies
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christine Bandtlow
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rolf Heumann
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sigrun Korsching
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hermann Rohrer
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hans Thoenen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Davies, A., Bandtlow, C., Heumann, R. et al. Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor . Nature 326, 353–358 (1987). https://doi.org/10.1038/326353a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/326353a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing