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Genetic linkage between X-chromosome markers and bipolar affective illness

Nature volume 326, pages 289–292 (1987)Cite this article

Abstract

A pedigree study shows close linkage of bipolar affective illness (manic depression) to the X-chromosome markers colour blindness and glucose-6-phosphate dehydrogenase deficiency. The maximum lod score ranges from 7.52 (assuming homogeneity) to 9.17 (assuming heterogeneity); that is, the odds in favour of linkage range between 3×107 to 1 and 109 to 1. These results provide confirmation that a major psychiatric disorder can be caused by a single genetic defect. As a possible first step in characterizing the primary genetic abnormality, this finding may have important implications for the aetiology, nosology, pathophysiology and, possibly, prevention and treatment of bipolar affective disorder. It also provides a means for identifying and characterizing homogeneous populations of patients and may help in clarifying aetiological heterogeneity.

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Author information

Author notes

  1. Robert H. Belmaker

    Present address: Beer-Sheva Mental Health Center, Beer-Sheva, Israel

Authors and Affiliations

  1. Department of Medical Genetics, New York State Psychiatric Institute,

    Miron Baron

  2. Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, 10032, USA

    Miron Baron

  3. Departments of Epidemiology and Public Health and of Human Genetics, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    Neil Risch

  4. Jerusalem Mental Health Center—Ezrath Nashim, and Department of Psychiatry, Hebrew University-Hadassah Medical School, Jerusalem, Israel

    Rahel Hamburger, Batsheva Mandel, Stuart Kushner, Michael Newman, Dov Drumer & Robert H. Belmaker

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  1. Miron Baron
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  2. Neil Risch
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  3. Rahel Hamburger
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  4. Batsheva Mandel
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  5. Stuart Kushner
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  6. Michael Newman
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  7. Dov Drumer
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  8. Robert H. Belmaker
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Baron, M., Risch, N., Hamburger, R. et al. Genetic linkage between X-chromosome markers and bipolar affective illness. Nature 326, 289–292 (1987). https://doi.org/10.1038/326289a0

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  • DOI: https://doi.org/10.1038/326289a0

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