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A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene

Nature volume 326, pages 42–47 (1987)Cite this article

Abstract

Complementary DNA cloning of the transcripts of the Drosophila clock gene period reveals three distinct transcripts. These result from unusual splicing pathways, one involving a CG 3′ splice site and one resulting in the use of two different reading frames in one exon, and they predict three separate proteins. Two of the cloned cDNAs can restore clock function to mutant arrhythmic flies.

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Author notes

  1. Yoav Citri

    Present address: Department of Biology, Brandeis University, Waltham, Massachusetts, 02254, USA

  2. Yoav Citri and David Baltimore: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA

Authors and Affiliations

  1. Department of Biology, Brandeis University, Waltham, Massachusetts, 02254, USA

    Yoav Citri, Hildur V. Colot, Agnes C. Jacquier, Qiang Yu, Jeffrey C. Hall, David Baltimore & Michael Rosbash

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  1. Yoav Citri
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  3. Agnes C. Jacquier
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Citri, Y., Colot, H., Jacquier, A. et al. A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene. Nature 326, 42–47 (1987). https://doi.org/10.1038/326042a0

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