The use of DNA markers has shown that manic-depressive illness can be caused by a single gene. These markers will not be useful for screening but may lead to fundamental insight into the disease.
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Robertson, M. Molecular genetics of the mind. Nature 325, 755 (1987). https://doi.org/10.1038/325755a0
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DOI: https://doi.org/10.1038/325755a0