Abstract
Some site-specific recombination systems require the interacting DNA sequences to have a specific relative orientation. This means that DNA segments can sense each other's direction even though they may be separated by many thousands of base pairs. Here, we review the surprising results of recent experiments that lead to a new model which accounts for site orientation specificity and relates it to other recombination systems where relative orientation is not critical.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Reed, R. R. Cell 25, 713–719 (1981).
Kitts, P. A., Symington, L. S., Dyson, P. & Sherratt, D. J. EMBO J. 2, 1055–1060 (1983).
Plasterk, R. H. A., Ilmer, T. A. M. & van de Putte, P. Virology 127, 24–36 (1983).
Johnson, R. C., Bruist, M. F., Glaccum, M. B. & Simon, M. I. Cold Spring Harbor Symp. quant. Biol. 49, 751–760 (1984).
Howe, M. M. & Schumm, J. W. Cold Spring Harb. Symp. quant. Biol. 45, 337–346 (1981).
Mizuuchi, K. Cell 35, 785–794 (1983).
Mizuuchi, K., Fisher, L. M., O'Dea, M. H. & Gellert, M. Proc. natn. Acad. Sci. U.S.A. 77, 1847–1851 (1980).
Pollock, T. J. & Nash, H. A. J. molec. Biol. 170, 1–18 (1983).
Bliska, J. & Cozzarelli, N. J. molec. Biol. (in the press).
Mizuuchi, K., Gellert, M., Weisberg, R. A. & Nash, H. A. J. molec. Biol. 141, 485–494 (1980).
Spengler, S. J., Stasiak, A. & Cozzarelli, N. R. Cell 42, 325–334 (1985).
Mizuuchi, K. & Mizuuchi, M. Cold Spring Harb. Symp. quant. Biol. 43, 1111–1114 (1979).
Abremski K., Hoess, R. & Sternberg, N. Cell 32, 1301–1311 (1983).
Lewis, S., Gifford, A. & Baltimore, D. Science 228, 677–685 (1985).
Ptashne, M. Nature 322, 697–701 (1986).
Krasnow, M. A. & Cozzarelli, N. R. Cell 32, 1313–1324 (1983).
Craig, N. L. & Nash, H. A. in Mechanisms of DNA Replication and Recombination (ed. Cozzarelli, N. R.) 617–636 (Liss, New York, 1983).
Benjamin, H. W., Matzuk, M. M., Krasnow, M. A. & Cozzarelli, N. R. Cell 40, 147–158 (1985).
Boocock, M. R., Brown, J. L. & Sherratt, D. J. Biochem. Soc. Trans. 14, 214–216 (1985).
Craigie, R. & Mizuuchi, K. Cell 45, 795–800 (1986).
Boocock, M. R., Brown, J. L. & Sherratt, D. J. in DNA Replication and Recombination (eds Kelly, T. J., Jr. & McMacken, R.) (Liss, New York, in the press).
Wasserman, S. A. & Cozzarelli, N. R. Proc. natn. Acad. Sci. U.S.A. 82, 1079–1083 (1985).
Wasserman, S. A., Dungan, J. M. & Cozzarelli, N. R. Science 229, 171–174 (1985).
Dynan, W. S. & Tjian, R. Nature 316, 774–778 (1985).
Echols, H. Science 233, 1050–1056 (1986).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gellert, M., Nash, H. Communication between segments of DNA during site-specific recombination. Nature 325, 401–404 (1987). https://doi.org/10.1038/325401a0
Issue Date:
DOI: https://doi.org/10.1038/325401a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
