Abstract
Subunits ofguanine nucleotide regulatory proteins purified from bovine cerebral cortex were used to perfuse the intracellular surface of excised patches of chick embryonic atrial cells. Single-channel current measurements unexpectedly indicate that the βγ, and not the a subunits, are responsible for activating the muscarinic-gated potassium channel.
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- David E. Clapham
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Logothetis, D., Kurachi, Y., Galper, J. et al. The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. Nature 325, 321–326 (1987). https://doi.org/10.1038/325321a0
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DOI: https://doi.org/10.1038/325321a0
