Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

Nature volume 325, pages 223–228 (1987)Cite this article

Abstract

Transgenic mice expressing simian virus 40 T antigen under control of the insulin gene regulatory region vary in their response to this protein. Each lineage is characteristically either tolerant to T antigen, or not, in which case autoantibodies arise with high frequency, and lymphocytes infiltrate and disrupt the pancreatic islets. Both non-tolerance and the autoimmune response appear to result from delayed onset of T antigen expression during β cell development.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

Buy

All prices are NET prices.

References

  1. Weigle, W. O. Adv. Immun. 16, 61–123 (1973).

    CAS  Article  Google Scholar 

  2. Howard, J. G. & Mitchison, N. A. Prog. Allergy 18, 43–96 (1975).

    CAS  PubMed  Google Scholar 

  3. Nossal, G. J. V. A. Rev. Immun. 1, 33–62 (1983).

    CAS  Article  Google Scholar 

  4. Smith, H. R. & Steinberg, A. D. A. Rev. Immun. 1, 175–210 (1981).

    Article  Google Scholar 

  5. Baekkeskov, S., Christie, M. & Lernmark, A. in Immunology of Endocrine Diseases (ed. A. McGregor) 73–88 (MTP Press, Lancaster) (1986).

    Book  Google Scholar 

  6. Srikanta, S., Ganda, O. P., Eisenbarth, G. S. & Soeldner, J. S. N. Eng. J. Med. 308, 322–325 (1983).

    CAS  Article  Google Scholar 

  7. Hanahan, D. Nature 315, 115–122 (1985).

    ADS  CAS  Article  Google Scholar 

  8. Gluzman, Y. Cell 23, 175–182 (1981).

    CAS  Article  Google Scholar 

  9. Harlow, E., Crawford, L. V., Pim, D. C. & Williamson, N. M. J. Virol. 39, 861–869 (1981).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Palmiter, R. & Brinster, B. A. Rev. Genet. 20, 465–499 (1986).

    CAS  Article  Google Scholar 

  11. Ornitz, D. M. et al. Nature 313, 600–602 (1985).

    ADS  CAS  Article  Google Scholar 

  12. Mitchison, N. A. Clin. Immun. Newsletter 6, 1–12 (1985).

    Article  Google Scholar 

  13. Rossini, A. A., Mordes, J. P. & Like, A. A. An. Rev. Immun. 3, 289–320 (1985).

    CAS  Article  Google Scholar 

  14. Bottazo, G. F., Gorsuch, A. N., Dean, B. M., Cudworth, A. G. & Doniach, D. Lancet i, 668–672 (1980).

    Article  Google Scholar 

  15. Lernmark, A. et al. N. Engl. J. Med. 299, 375–380 (1978).

    CAS  Article  Google Scholar 

  16. Geps, W. & LeCompte, P. M. Am. J. Med. 70, 105–115 (1981).

    Article  Google Scholar 

  17. Bottazo, G. F. et al. New Engl. J. Med. 313, 353–360 (1985).

    Article  Google Scholar 

  18. Baekkeskov, S., Dynberg, T. & Lernmark, A. Science 224, 1348–1350 (1984).

    ADS  CAS  Article  Google Scholar 

  19. Baekkeskov, S. et al. J. clin. Invest. (in the press).

  20. Harlow, E., Williamson, N. M., Ralston, R., Helfman, D. M. & Adams, T. E. Molec. cell. Biol. 5, 1601–1610 (1985).

    CAS  Article  Google Scholar 

  21. Tevethia, S. S., Flyer, D. C. & Tjian, R. Virology 107, 13–23 (1980).

    CAS  Article  Google Scholar 

  22. Pfizenmaier, K., Pan, S. & Knowles, B. B. J. Immun. 124, 1888–1891 (1980).

    CAS  PubMed  Google Scholar 

  23. Abramczuk, J., Pan, S., Maul, G. & Knowles, B. B. J. Viol. 49, 540–548 (1984).

    CAS  Google Scholar 

  24. Sternberger, L. A. Immunocytochemistry, 2nd edn (Wiley, New York, 1979).

    Google Scholar 

Download references

Author information

Author notes

  1. Timothy E. Adams

    Present address: Dept of Preclinical Veterinary Science, University of Melbourne, Parkville, Victoria, 3052, Australia

  2. Douglas Hanahan: To whom correspondence should be addressed.

Affiliations

  1. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 11724, USA

    Timothy E. Adams, Susan Alpert & Douglas Hanahan

Authors
  1. Timothy E. Adams
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Susan Alpert
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Douglas Hanahan
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Adams, T., Alpert, S. & Hanahan, D. Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells. Nature 325, 223–228 (1987). https://doi.org/10.1038/325223a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/325223a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing