Abstract
Transgenic mice expressing simian virus 40 T antigen under control of the insulin gene regulatory region vary in their response to this protein. Each lineage is characteristically either tolerant to T antigen, or not, in which case autoantibodies arise with high frequency, and lymphocytes infiltrate and disrupt the pancreatic islets. Both non-tolerance and the autoimmune response appear to result from delayed onset of T antigen expression during β cell development.
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References
Weigle, W. O. Adv. Immun. 16, 61–123 (1973).
Howard, J. G. & Mitchison, N. A. Prog. Allergy 18, 43–96 (1975).
Nossal, G. J. V. A. Rev. Immun. 1, 33–62 (1983).
Smith, H. R. & Steinberg, A. D. A. Rev. Immun. 1, 175–210 (1981).
Baekkeskov, S., Christie, M. & Lernmark, A. in Immunology of Endocrine Diseases (ed. A. McGregor) 73–88 (MTP Press, Lancaster) (1986).
Srikanta, S., Ganda, O. P., Eisenbarth, G. S. & Soeldner, J. S. N. Eng. J. Med. 308, 322–325 (1983).
Hanahan, D. Nature 315, 115–122 (1985).
Gluzman, Y. Cell 23, 175–182 (1981).
Harlow, E., Crawford, L. V., Pim, D. C. & Williamson, N. M. J. Virol. 39, 861–869 (1981).
Palmiter, R. & Brinster, B. A. Rev. Genet. 20, 465–499 (1986).
Ornitz, D. M. et al. Nature 313, 600–602 (1985).
Mitchison, N. A. Clin. Immun. Newsletter 6, 1–12 (1985).
Rossini, A. A., Mordes, J. P. & Like, A. A. An. Rev. Immun. 3, 289–320 (1985).
Bottazo, G. F., Gorsuch, A. N., Dean, B. M., Cudworth, A. G. & Doniach, D. Lancet i, 668–672 (1980).
Lernmark, A. et al. N. Engl. J. Med. 299, 375–380 (1978).
Geps, W. & LeCompte, P. M. Am. J. Med. 70, 105–115 (1981).
Bottazo, G. F. et al. New Engl. J. Med. 313, 353–360 (1985).
Baekkeskov, S., Dynberg, T. & Lernmark, A. Science 224, 1348–1350 (1984).
Baekkeskov, S. et al. J. clin. Invest. (in the press).
Harlow, E., Williamson, N. M., Ralston, R., Helfman, D. M. & Adams, T. E. Molec. cell. Biol. 5, 1601–1610 (1985).
Tevethia, S. S., Flyer, D. C. & Tjian, R. Virology 107, 13–23 (1980).
Pfizenmaier, K., Pan, S. & Knowles, B. B. J. Immun. 124, 1888–1891 (1980).
Abramczuk, J., Pan, S., Maul, G. & Knowles, B. B. J. Viol. 49, 540–548 (1984).
Sternberger, L. A. Immunocytochemistry, 2nd edn (Wiley, New York, 1979).
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Adams, T., Alpert, S. & Hanahan, D. Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells. Nature 325, 223–228 (1987). https://doi.org/10.1038/325223a0
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DOI: https://doi.org/10.1038/325223a0
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