Abstract
The genes encoding the α and β chains of the T-cell receptor (Ti) of an antigen-specific, Ia-restricted murine T-cell hybridoma were introduced into T3-positive or T3-negative human T cells. The resultant transfectants express either mouse-human or mouse-mouse Ti αβ molecules functionally associated with the human T3 complex. Only the complete murine Ti aft dimer mediates specific functional corecognition of the appropriate antigen-la pair.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Schwartz, R. H. A. Rev. Immun. 3, 237–261 (1985).
Allison, J. P., McIntyre, B. W. & Bloch, D. J. Immun. 129, 2293–2300 (1982).
Meuer, S. C. et al. J. exp. Med. 157, 705–719 (1983).
Haskins, K. et al. J. exp. Med. 157, 1149–1169 (1983).
Samelson, L. E., Germain, R. N. & Schwartz, R. H. Proc. natn. Acad. Sci. U.S.A. 80, 6972–6976 (1983).
Reinherz, E. L. et al. Cell 30, 735–743 (1982).
Borst, J., Alexander, S., Elder, J. & Terhorst, C. J. biol. Chem. 258, 5135–5141 (1983).
Allison, J. P. & Lanier, L. L. Nature 314, 107–109 (1985).
Samelson, L. E., Harford, J. B. & Klausner, R. D. Cell 43, 223–231 (1985).
Hedrick, S. M., Nielsen, E. A., Kavaler, J., Cohen, D. I. & Davis, M. M. Nature 308, 153–158 (1984).
Yanagi, Y. et al. Nature 308, 145–149 (1984).
Chien, Y.-H. et al. Nature 312, 31–36 (1984).
Saito, H. et al. Nature 312, 36–40 (1984).
Kronenberg, M., Siu, G., Hood, L. E. & Shastri, N. A. Rev. Immun. 4, 529–591 (1986).
Yagüe, J. et al. Cell 42, 81–87 (1985).
Dembic, Z. et al. Nature 320, 232–238 (1986).
Weiss, A., Wiskocil, R. L. & Stobo, J. D. J. Immun. 133, 123–128 (1984).
Weiss, A. & Stobo, J. J. exp. Med. 160, 1284–1299 (1984).
Ohashi, P. S. et al. Nature 316, 606–609 (1985).
Van Wauwe, J. P., DeMey, J. R. & Goosens, J. G. J. Immun. 124, 2708–2713 (1980).
Hedrick, S. M. et al. Cell 30, 141–152 (1982).
Winoto, A., Mjolsness, S. & Hood, L. Nature 316, 832–836 (1985).
Yoshikai, Y. et al. Nature 316, 837–840 (1985).
Sandri-Goldin, R. M., Goldin, A. L., Levine, M. & Glorioso, J. C. Molec. cell. Biol. 1, 743–752 (1981).
Germain, R. N., Norcross, M. A. & Margulies, D. H. Nature 306, 190–194 (1983).
Boyse, E. A., Stockert, E. & Old, L. J. Proc. natn. Acad. Sci. U.S.A. 58, 954–957 (1967).
Reinherz, E. L. et al. Cell 30, 735–743 (1982).
Brenner, M. B. et al. Nature 322, 145–149 (1986).
Bank, I. et al. Nature 322, 179–181 (1986).
Weiss, A., Newton, M. & Crommie, D. Proc. natn. Acad. Sci. U.S.A. 83, 6998–7002 (1986).
Gunter, K. C., Kroczek, R. A., Shevach, E. M. & Germain, R. N. J. exp. Med. 163, 285–300 (1986).
Chien, Y.-H. et al. Nature 309, 322–326 (1984).
Mulligan, R. C. & Berg, P. Proc. natn. Acad. Sci. U.S.A. 78, 2072–2076 (1981).
Becker, D. M. et al. Nature 317, 430–434 (1985).
Barth, R. K. et al. Nature 316, 517–523 (1985).
Ronchese, F., Schwartz, R. H. & Germain, R. H. (in preparation).
Kappler, J. et al. Proc. natn. Acad. Sci. U.S.A. 79, 3604–3607 (1982).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Saito, T., Weiss, A., Miller, J. et al. Specific antigen—la activation of transfected human T cells expressing murine Ti αβ —human T3 receptor complexes. Nature 325, 125–130 (1987). https://doi.org/10.1038/325125a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/325125a0
This article is cited by
-
A phase I clinical trial of adoptive transfer of folate receptor-alpha redirected autologous T cells for recurrent ovarian cancer
Journal of Translational Medicine (2012)
-
High-avidity human IgGκ monoclonal antibodies from a novel strain of minilocus transgenic mice
Nature Biotechnology (1996)
-
Antigen-specific, MHC-unrestricted T cells
Biotherapy (1992)
-
T cell targeting in cancer therapy
Cancer Immunology Immunotherapy (1991)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
