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The c-erb-A protein is a high-affinity receptor for thyroid hormone

Abstract

Hormone binding and localization of the c-erb-A protein suggest that it is a receptor for thyroid hormone, a nuclear protein that binds to DNA and activates transcription. In contrast, the product of the viral oncogene v-erb-A is defective in binding the hormone but is still located in the nucleus.

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Sap, J., Muñoz, A., Damm, K. et al. The c-erb-A protein is a high-affinity receptor for thyroid hormone. Nature 324, 635–640 (1986). https://doi.org/10.1038/324635a0

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