Interleukin-1 (IL-1) is a factor that can induce proliferation of murine T lymphocytes1,2 and can elicit a variety of other biological responses. These include bone resorption3, fibroblast proliferation4, acute phase protein release from hepatocytes5, cartilage breakdown6 and fever7. This spectrum of activities is consistent with a role for IL-1 as a mediator of inflammation. Recently, sequence data have shown that there are at least two members of the IL-1 family; these distantly related proteins have been termed IL-1α and IL-1β8–11. We have found previously that both murine T cells and fibroblasts possess a relative molecular mass (Mr) ∼80,000 (80K) plasma membrane receptor for human IL-1β12,13. We show here that the receptor for IL-1α on both murine and human cells is identical to that for IL-1β. This result raises the issue of what separation, if any, there might be between the biological activities of IL-1α and IL-1β.
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Dower, S., Kronheim, S., Hopp, T. et al. The cell surface receptors for interleukin-1α and interleukin-1β are identical. Nature 324, 266–268 (1986). https://doi.org/10.1038/324266a0
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