Abstract
Allogeneic reactions are the major limitation to organ transplantation. These are manifested as rejection of the grafted tissue, and also, in the case of bone marrow transplantation (BMT), graftversus-host disease (GVHD)1. Recent methods of avoiding GVHD,by depleting T cells from donor marrow, have led to an increased incidence of marrow graft rejection2–5. Current recipient conditioning protocols involving drugs or irradiation cannot safely be increased, so alternatives must be found. Monoclonal antibodies can be used to control immune responses in vivo6,7, and would be useful in this context if we could define and deplete the cells responsible for marrow rejection. We show here that elimination of residual L3T4+ and Lyt-2+ cells from mice receiving fully mismatched bone marrow abrogates rejection and promotes tolerance to donor-type skin grafts, even in sub-lethally irradiated recipients.
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References
Vriesendorp, H. M. in Bone Marrow Transplantation. Biological Mechanisms and Clinical Practice (eds van Bekkum, D. W. & Lowenberg, B.) 73–146 (Dekker, New York, 1985).
Waldmann, H. et al. Lancet ii, 483–486 (1984).
Sondel, P. M. et al. Transplantn Proc. 17, 460–461 (1985).
O'Reilly, R. J. et al. Transplant Proc. 17, 455–459 (1985).
Martin, P J., Hansen, J. A., Storb, R. & Thomas, E. D. Transplantn Proc. 17, 486–487 (1985).
Cobbold, S. P., Jayasuriya, A., Nash, A., Prospero, T. D. & Waldmann, H. Nature 312, 548–551 (1984).
Ortho Multicentre Transplant Study Group New Engl. J. Med. 313, 337–342 (1985).
Rodt, H., Thierfelder, S. & Eulitz, M. Eur. J. Immun. 4, 25–29 (1974).
Trentin, J. J. & Judd, K. P. Transplantn Proc. 5, 865–868 (1973).
Prentice, H. G. et al. Lancet i, 472–476 (1984).
Cudkowicz, G. & Bennett, M. J. exp. Med. 134, 1513 (1971).
Waterfall, M., Rayfield, L. S. & Brent, L. Nature 311, 663–665 (1984).
Warner, J. F. & Dennert, G. J. exp. Med. 161, 563–576 (1985).
Cobbold, S., Martin, G. & Waldmann, H. Transplantation 42 (in the press).
Sprent, J. & Schaefer, M. J. exp. Med. 162, 2068 (1985).
Katz, D. H., Hamoaka, T. & Benacerraf, B. J. exp. Med. 137, 1405–1418 (1973).
Dialynas, D. P. et al. Immun. Rev. 74, 29–56 (1983).
Bernard, A., Boumsell, L. & Hill, C. in Leucocyte Typing: Human Leucocyte Differentiation Antigens Detected by Monoclonal Antibodies Specification-Classification-Nomenclature (eds Bernard, A. et al.) (Springer, New York, 1984).
Zinkernagel, R. M. & Doherty, P. C. Nature 251, 547–548 (1974).
MacDonald, H. R., Thiernesse, N. & Cerottini, J. C. J. Immun. 126, 1671 (1981).
Cobbold, S. P. & Waldmann, H. Transplantation 41, 634 (1986).
Mizuochi, T. et al. J. exp. Med. 162, 427–443 (1985).
Hughes-Jones, N. C., Gorick, B. D., Miller, N. G. A. & Howard, J. C. Eur. J. Immun. 14, 974–978 (1984).
Bindon, C. I., Hale, G., Clark, M. R. & Waldmann, H. Transplantation 40, 538–544 (1985).
Benjamin, R. & Waldmann, H. Nature 320, 449–451 (1986).
Peto, R. et al. Br. J. Cancer 35, 1–39 (1977).
Koch, S., Koch, N., Robinson, P. & Hammerling, G. Transplantation 36, 177–180 (1983).
Billingham, R. E., Brent, L. & Medawar, P. B. Proc. R. Soc. B143, 58 (1954).
Aqel, N. M., Clark, M., Cobbold, S. P. & Waldmann, H. J. immun. Meth. 69, 207–214 (1984).
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Cobbold, S., Martin, G., Qin, S. et al. Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance. Nature 323, 164–166 (1986). https://doi.org/10.1038/323164a0
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DOI: https://doi.org/10.1038/323164a0
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