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A second post-transcriptional trans-activator gene required for HTLV-III replication

Nature volume 321, pages 412417 (22 May 1986) | Download Citation

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Abstract

Evidence is provided for the existence of a seventh gene in the genome of human T-lymphotropic virus type III/lymphadenopathy-associated virus. The gene is necessary for replication and acts post-transcriptionally to relieve negative regulation of the messenger RNA for the virion capsid and envelope proteins. These observations suggest mechanisms for regulating both the latent and lytic phases of the virus life cycle.

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Affiliations

  1. Dana-Farber Cancer Institute, Department of Pathology, Harvard Medical School, Massachusetts 02115, USA

    • Joseph Sodroski
    • , Wei Chun Goh
    • , Craig Rosen
    • , Andrew Dayton
    •  & Ernest Terwilliger
  2. Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA

    • William Haseltine

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https://doi.org/10.1038/321412a0

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