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A novel type of human papillomavirus associated with genital neoplasias

Nature volume 321, pages 246–249 (1986)Cite this article

Abstract

The role of human papillomaviruses (HPVs) in the development of genital neoplasias has been well documented1–5. The genomes of two HPV types, HPV16 and HPV18, have been found to be associated with about 70% of invasive carcinomas of the uterine cervix2,4,6. As, under non-stringent hybridization conditions, HPV DNA sequences have been detected in about 90% of cervical carcinomas4,6, it seems likely that additional HPV types are associated with these tumours. Here we report the molecular cloning and characterization of a novel HPV type, tentatively named HPV33, whose sequences have been detected in 4–8% of biopsies of genital intra-epithelial neoplasias and cervical invasive carcinomas, usually as free monomeric or oligomeric molecules. However, in one specimen of vulvar Bowen's disease, HPV33 DNA sequences were integrated in the host-cell genome. Thus, HPV33 probably represents an additional type of potentially oncogenic genital HPV.

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Author information

Authors and Affiliations

  1. Unité des Papillomavirus, INSERM U190, Institut Pasteur, 75015, Paris, France

    Sylvie Beaudenon, Dina Kremsdorf, Odile Croissant & Gérard Orth

  2. Unité de Recombinaison et Expression Génétique, INSERM U163, Institut Pasteur, 75015, Paris, France

    Simon Wain-Hobson

  3. Department of Dermatology, Warsaw School of Medicine, Warsaw, Poland

    Stefania Jablonska

Authors
  1. Sylvie Beaudenon
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  2. Dina Kremsdorf
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  3. Odile Croissant
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  4. Stefania Jablonska
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  5. Simon Wain-Hobson
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  6. Gérard Orth
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Beaudenon, S., Kremsdorf, D., Croissant, O. et al. A novel type of human papillomavirus associated with genital neoplasias. Nature 321, 246–249 (1986). https://doi.org/10.1038/321246a0

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