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Correlations between T-cell specificity and the structure of the antigen receptor

Nature volume 321, pages 219226 (15 May 1986) | Download Citation

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Abstract

The derived amino-acid sequences of the heterodimeric antigen receptors expressed by a series of murine T-cell clones are presented. A comparison of the receptor sequences indicates that several mechanisms for generating receptor diversity can influence T-cell specificity, including junctional diversity, combinatorial joining, and combinatorial chain associations.

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Affiliations

  1. Department of Biology, Cancer Center, M-001, University of California, San Diego, La Jolla, California 92093, USA.

    • Pamela J. Fink
    • , David L. McElligott
    •  & Stephen M. Hedrick
  2. Medicine Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.

    • Louis A. Matis
    •  & Michael Bookman

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https://doi.org/10.1038/321219a0

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