Abstract
A leucine transfer RNA has been transformed into a serine transfer RNA by changing 12 nucleotides. This result indicates that a limited set of residues determine tRNA identity.
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References
Chapeville, F. et al. Proc. nain. Acad. Sci. U.S.A. 48, 1086–1092 (1962).
Crick, F. H. C. J. molec. Biol. 19, 548–555 (1966).
Sprinzl, M., Moll, J., Meissner, F. & Hartmann, T. Nucleic Acids Res. 13, r1–r49 (1985).
Holley, R. W. et al. Science 147, 1462–1465 (1965).
Robertus, J. D. et al. Nature 250, 546–551 (1974).
Kim, S. H. et al. Science 185, 435–440 (1974).
Schevitz, R. W. et al. Nature 278, 188–190 (1979).
Westhof, E., Dumas, P. & Moras, D. J. molec. Biol. 184, 119–145 (1985).
Schimmel, P. R. & Söll, D. A. Rev. Biochem. 48, 601–648 (1979).
Rich, A. & Schimmel, P. R. Nucleic Acids Res. 4, 1649–1665 (1977).
Schimmel, P. R. Acts chem. Res. 10, 411–418 (1977).
Schimmel, P. R. in Transfer RNA: Structure, Properties and Recognition (eds Schimmel, P. R., Söll, D. & Abelson, J.) 297–310 (Cold Spring Harbor Laboratory, New York, 1979).
Schulman, L. H., Pelka, H. & Susani, M. Nucleic Acids Res. 11, 1439–1455 (1983).
Schulman, L. H. & Pelka, H. Proc. natn. Acad. Sci. U.S.A. 80, 6755–6759 (1983).
Schulman, L. H. & Pelka, H. Biochemistry (in the press).
Hooper, M. L., Russell, R. L. & Smith, J. D. FEBS Lett. 22, 149–155 (1972).
Shimura, Y. et al. FEBS Lett. 22, 144–148 (1972).
Ghysen, A., Reyes, O., Allende, C. C. & Allende, J. E. in Gene Expression and Its Regulation (eds Kenney et al.) 209–216 (Plenum, New York, 1973).
Ozeki, H. et al. in Transfer RNA: Biological Aspects (eds Schimmel, P. R., Söll, D. & Abelson, J.) 341–362 (Cold Spring Harbor Laboratory, New York, 1980).
Goodman, H. M., Abelson, J., Landy, A., Brenner, S. & Smith, J. D. Nature 217, 1019–1024 (1968).
Steege, D. A. & Söll, D. in Biological Regulation and Development Vol. 1 (ed. Goldberger, R. F.) 433–485 (Plenum, New York, 1979).
Smith, J. D. & Celis, J. E. Nature new Biol. 243, 66–71 (1973).
Celis, J. E., Hooper, M. L. & Smith, J. D. Nature new Biol. 244, 261–264 (1973).
Inokuchi, H., Celis, J. E. & Smith, J. D. J. molec. Biol. 85, 187–192 (1974).
Ghysen, A. & Celis, J. E. J. molec. Biol. 83, 333–351 (1974).
Yaniv, M., Folk, W. R., Berg, P. & Soil, L. J. molec. Biol. 86, 245–260 (1974).
Khorana, H. G. Science 203, 614–625 (1979).
Brennan, T. & Sundaralingam, M. Nucleic Acids Res. 3, 3235–3251 (1976).
Steege, D. A. Nucleic Acids Res. 11, 3823–3832 (1983).
Yamada, Y. & Ishikura, H. FEBS Lett. 29, 231–234 (1973).
Ish-Horowicz, D. & Clark, B. F. C. J. biol. Chem. 248, 6663–6673 (1973).
Ishikura, H., Yamada, Y. & Nishimura, S. FEBS Lett. 16, 68–70 (1971).
McClain, W. H., Barrell, B. G. & Seidman, J. G. J. molec. Biol. 99, 717–732 (1975).
Grosjean, H., Nicoghosian, K., Haumont, E., Söll, D. & Cedergren, R. Nucleic Acids Res. 13, 5697–5706 (1985).
Roe, B., Sirover, M. & Dudock, B. Biochemistry 12, 4146–4154 (1973).
Bruce, G. A. & Uhlenbeck, O. C. Biochemistry 21, 3921–3926 (1982).
Kisselev, L. L. Prog. Nucleic Acids Res. molec. Biol. 32, 237–266 (1985).
Yoshimura, M., Inokuchi, H. & Ozeki, H. J. molec. Biol. 177, 627–644 (1984).
Thorbjarnardóttir, S. et al. J. Bact. 161, 219–222 (1985).
Young, R. A. J. biol. Chem. 254, 12725–12731 (1979).
Abelson, J. A. Rev. Biochem. 48, 1035–1069 (1979).
Miller, J. H. & Albertini, A. M. J. molec. Biol. 164, 59–71 (1983).
Dente, L., Cesareni, G. & Cortese, R. Nucleic Acids Res. 11, 1645–1655 (1983).
Miller, J. H. in Experiments in Molecular Genetics, 352–355 (Cold Spring Harbor Laboratory, New York, 1972).
Knott-Hunziker, V., Waley, S. G., Orlek, B. S. & Sammes, P. G. FEBS Lett. 99, 59–61 (1979).
Dalbadie-McFarland, G. et al. Proc. natn. Acad. Sci. U.S.A. 79, 6409–6413 (1982).
Ambler, R. P. Phil Trans. R. Soc. B289, 321–331 (1980).
Fisher, J., Belasco, J. G., Khosla, S. & Knowles, J. R. Biochemistry 19, 2895–2901 (1980).
Sigal, I. S., Harwood, B. G. & Arentzen, R. Proc. natn. Acad. Sci. U.S.A. 79, 7157–7160 (1982).
Sigal, I. S., DeGrado, W. F., Thomas, B. J. & Petteway, S. R. J. biol. Chem. 259, 5327–5332 (1984).
Dalbadie-McFarland, G., Neitzel, J. J. & Richards, J. H. Biochemistry (in the press).
Smith, D. R. & Calvo, J. M. Nucleic Acids Res. 8, 2255–2274 (1980).
Amann, E., Brosius, J. & Ptashne, M. Gene 25, 167–178 (1983).
Edman, P. & Begg, G. Eur. J. Biochem. 1, 80–91 (1967).
Bolin, J. T., Filman, D. J., Matthews, D. A., Hamlin, R. C. & Kraut, J. J. biol Chem. 257, 13650–13662 (1982).
Matthews, D. A. et al. Science 197, 452–455 (1977).
Filmann, D. J., Bolin, J. T., Matthews, D. A. & Kraut, J. J. biol. Chem. 257, 13663–13672 (1982).
Hewick, R. M., Hunkapiller, M. W., Hood, L. E. & Dreyer, W. J. J. biol Chem. 256, 7990–7997 (1981).
Yamaizumi, Z., Kuchino, Y., Harada, F., Nishimura, S. & McCloskey, J. A. J. biol Chem. 2220–2225 (1980).
Yarus, M., McMillan, C., Cline, S., Bradley, D. & Snyder, M. Proc. natn. Acad. Sci. U.S.A. 77, 5082–5096 (1980).
Maniatis, T., Fritsch, E. F. & Sambrook, J. in Molecular Cloning: A Laboratory Manual, 320–321 (Cold Spring Harbor Laboratory, New York, 1982).
Denhardt, D. T. Biochem. biophys. Res. Commun. 23, 641–646 (1966).
Maniatis, T., Fritsch, E. F. & Sambrook, J. in Molecular Cloning: A Laboratory Manual, 447 (Cold Spring Harbor Laboratory, New York, 1982).
Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).
Newman, A. J., Ogden, R. C. & Abelson, J. Cell 35, 117–125 (1983).
Villafranca, J. E. et al. Science 222, 782–788 (1983).
Baccanari, D., Phillips, A., Smith, S., Sinski, D. & Burchall, J. Biochemistry 14, 5267–5273 (1975).
Baccanari, D. P., Averett, D., Briggs, C. & Burchall, J. Biochemistry 16, 3566–3572 (1977).
Baccanari, D. P., Stone, D. & Kuyper, L. J. biol Chem. 256, 1738–1747 (1981).
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Normanly, J., Ogden, R., Horvath, S. et al. Changing the identity of a transfer RNA. Nature 321, 213–219 (1986). https://doi.org/10.1038/321213a0
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DOI: https://doi.org/10.1038/321213a0
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