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Neural control of the forms of acetylcholinesterase in slow mammalian muscles

Naturevolume 321pages7274 (1986) | Download Citation



The ‘heavy’, collagen-tailed form of acetylcholinesterase (AChE), having a s20,w° of 16S in mammals, occurs at vertebrate muscle endplates and has been widely regarded as a marker of neuronal influence on muscle in vivo1–5. However, an interesting exception has been described by Bacou et al., in a previous report in Nature6. They found, in a slow-twitch muscle of the rabbit, that after denervation the 16S form of AChE increases markedly, rather than disappearing. Such a phenomenon would modify current concepts of neuromuscular regulation. We report here, however, that this exception is apparent rather than real in terms of endplate AChE regulation.

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  1. 1

    Lyles, J. M., Silman, I., Di Giamberardino, L., Couraud, J. Y. & Barnard, E. A. J. Neurochem. 38, 1007–1021 (1982).

  2. 2

    Massoulié, J. M. & Bon, S. A. Rev. Neurosci. 5, 57–106 (1982).

  3. 3

    Hall, Z. W. J. Neurobiol. 4, 343–361 (1973).

  4. 4

    Randall, W. R., Lai, J. & Barnard, E. A. in Molecular Basis of Nerve Activity (eds Changeux, J.-P., Hucho, R, Maelicke, A. & Neumann, E.) 595–618 (de Gruyter, Berlin, 1985).

  5. 5

    Vigny, M., Koenig, J. & Rieger, F. J. Neurochem. 27, 1347–1353 (1976).

  6. 6

    Bacou, F., Vigneron, P. & Massoulié, J. Nature 296, 661–664 (1982).

  7. 7

    Kerr, N. S. Anat. Rec. 121, 481 (1955).

  8. 8

    Narone, R., Pavaux, C., Blin, P. C. & Cuq, P. Atlas D'Anatomie du Lapin (Masson, Paris, 1973).

  9. 9

    Peter, J. B., Barnard, P. J., Edgerton, V. R., Gillespie, C. A. & Stempel, K. E. Biochemistry 11, 2627–2633 (1972).

  10. 10

    Silman, I., Di Giamberardino, L., Lyles, J. M., Couraud, J. Y. & Barnard, E. A. Nature 280, 160–162 (1980).

  11. 11

    Collins, P. L. & Younkin, S. G. J. biol Chem. 257, 13638–13644 (1982).

  12. 12

    Tennyson, V. M., Kremzner, L. T. & Brzin, M. J. Neuropath, exp. Neurol. 36, 245–275 (1977).

  13. 13

    Betz, W. J., Caldwell, J. H. & Ribchester, R. R. J. Physiol., Lond. 303, 265–280 (1980).

  14. 14

    Jedrzejczyk, J., Silman, I., Lyles, J. M. & Barnard, E. A. Biosci. Rep. 1, 45–51 (1981).

  15. 15

    Jedrzejczyk, J., Silman, I., Lai, J. & Barnard, E. A. Neurosci. Lett. 46, 283–289 (1984).

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Author notes

    • Josephine Lai

    Present address: Laboratory of Neurophysiology, NINCOS, NIH, Bethesda, Maryland, 20205, USA

    • John A. Pizzey

    Present address: Biophysics Department, KQC Kensington Campus, London, W8 7AH, UK


  1. Department of Biochemistry, Imperial College of Science and Technology, London, SW7 2AZ

    • Josephine Lai
    • , Jolanta Jedrzejczyk
    • , John A. Pizzey
    • , David Green
    •  & Eric A. Barnard
  2. MRC Molecular Neurobiology Unit, MRC Centre, Hills Road, Cambridge, CB2 2QH, UK

    • Josephine Lai
    • , Jolanta Jedrzejczyk
    • , John A. Pizzey
    • , David Green
    •  & Eric A. Barnard
  3. Department of Histology, Academy of Medicine, Warsaw, 02-004, Poland

    • Jolanta Jedrzejczyk


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