Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Expression of the c-myb proto-oncogene during cellular proliferation

Nature volume 319, pages 374–380 (1986)Cite this article

Abstract

In several cell types, messenger RNA levels of the nuclear proto-oncogene c-myb vary as a function of cellular proliferation ; a transient increase in c-myb steady-state mRNA, mediated by post-transcriptional mechanisms, occurs during cell-cycle progression. In contrast, both quiescent and proliferating immature thymocytes contain exceptionally high levels of c-myb mRNA as a consequence of increased c-myb transcription.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Heldin, C.-H. & Westermark, B. Cell 37, 9–20 (1984).

    Article  CAS  Google Scholar 

  2. Pardee, A. B., Campisi, J. & Croy, R. G. in Cancer Cells Vol. 3 (eds Feramisco, J., Ozanne B. & Stiles, C.) 389–392 (Cold Spring Harbor Laboratory, New York, 1985).

    Google Scholar 

  3. Hartwell, L. H., Culotti, J., Pringle, J. & Reid, B. Science 183, 46–51 (1974).

    Article  ADS  CAS  Google Scholar 

  4. Siminovitch, L. & Thompson, L. H. J. cell Physiol. 95, 361–366 (1978).

    Article  CAS  Google Scholar 

  5. Leys, E. J. & Kellems, R. E. Molec. cell. Biol. 1, 961–971 (1981).

    Article  CAS  Google Scholar 

  6. Farnham, P. J. & Schimke, R. T. J. biol. Chem. 260, 7675–7680 (1985).

    CAS  PubMed  Google Scholar 

  7. Groudine, M. & Casimir, C. Nucleic Acids Res. 12, 1427–1446 (1984).

    Article  CAS  Google Scholar 

  8. Thompson, C. B., Challoner, P. B., Neiman, P. E. & Groudine, M. Nature 314, 363–366 (1985).

    Article  ADS  CAS  Google Scholar 

  9. Storms, R. et al. Molec. cell. Biol. 4, 2858–2864 (1984).

    Article  CAS  Google Scholar 

  10. Eisenman, R. N., Tachibana, C. Y., Abrams, H. D. & Hann, S. Molec. cell. Biol. 5, 114–126 (1985).

    Article  CAS  Google Scholar 

  11. Curran, T., Miller, A. D., Zokas, L. & Verma, I. M. Cell 36, 259–268 (1984).

    Article  CAS  Google Scholar 

  12. Klempnauer, K.-H., Symonds, G., Evan, G. I. & Bishop, J. M. Cell 37, 537–547 (1984).

    Article  CAS  Google Scholar 

  13. Boyle, W. J., Lampert, M. A., Lipsick, J. S. & Baluda, M. A. Proc. natn. Acad. Sci. U.S.A. 81, 4265–4269 (1984).

    Article  ADS  CAS  Google Scholar 

  14. Kelly, K., Cochran, B. H., Stiles, C. D. & Leder, P. Cell 35, 603–610 (1983).

    Article  CAS  Google Scholar 

  15. Greenberg, M. E. & Ziff, E. B. Nature 311, 433–438 (1984).

    Article  ADS  CAS  Google Scholar 

  16. Muller, R., Bravo, R., Burckhardt, J. & Curran, T. Nature 312, 716–720 (1984).

    Article  ADS  CAS  Google Scholar 

  17. Kruijer, W., Cooper, J. A., Hunter, T. & Verma, I. M. Nature 312, 711–716 (1984).

    Article  ADS  CAS  Google Scholar 

  18. Muller, R., Curran, T., Muller, D. & Guilbert, L. Nature 314, 546–548 (1985).

    Article  ADS  CAS  Google Scholar 

  19. Hann, S. R., Thompson, C. B. & Eisenman, R. N. Nature 314, 366–369 (1985).

    Article  ADS  CAS  Google Scholar 

  20. Craig, R. W. & Bloch, A. Cancer Res. 44, 442–446 (1984).

    CAS  PubMed  Google Scholar 

  21. Gonda, T. J., Sheiness, D. K. & Bishop, J. M. Molec. cell. Biol. 2, 617–624 (1982).

    Article  CAS  Google Scholar 

  22. Westin, E. H. et al. Proc. natn. Acad. Sci. U.S.A. 79, 2194–2198 (1982).

    Article  ADS  CAS  Google Scholar 

  23. Coll, J. et al. Expl. Cell Res. 149, 151–162 (1983).

    Article  CAS  Google Scholar 

  24. Sheiness, D. & Gardinier, M. Molec. cell. Biol. 4, 1206–1212 (1984).

    Article  CAS  Google Scholar 

  25. Gonda, T. J. & Metcalf, D. Nature 310, 249–251 (1984).

    Article  ADS  CAS  Google Scholar 

  26. Chirgwin, J.M., Przbyla, A.E., MacDonald, R.J. & Rutter, W.J. Biochemistry 18, 5294–5299 (1979).

    Article  CAS  Google Scholar 

  27. Perbal, B. & Baluda, M. A. J. Virol. 41, 250–257 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  28. Dugaiczyk, A. et al. Biochemistry 22, 1605–1613 (1983).

    Article  CAS  Google Scholar 

  29. Dani, C. et al. Proc. natn. Acad. Sci. U.S.A. 81, 7046–7050 (1984).

    Article  ADS  CAS  Google Scholar 

  30. Stuart, P., Ito, M., Stewart, C. & Conrad, S. E. Molec. cell. Biol. 5, 1490–1497 (1985).

    Article  CAS  Google Scholar 

  31. Nilsson, G., Belasco, J. G., Cohen, S. N. & von Gabain, A. Nature 312, 75–77 (1984).

    Article  ADS  CAS  Google Scholar 

  32. Sittman, D. B., Graves, R. A. & Marzluff, W. F. Proc. natn. Acad. Sci. U.S.A. 80, 1849–1853 (1983).

    Article  ADS  CAS  Google Scholar 

  33. Linial, M., Gunderson, N. & Groudine, M. Science 230, 1126–1132, 1985.

    Article  ADS  CAS  Google Scholar 

  34. Krieg, P. A. & Melton, D. A. Nature 308, 203–206 (1984).

    Article  ADS  CAS  Google Scholar 

  35. Groudine, M., Peretz, M. & Weintraub, H. Molec. cell. Biol. 1, 281–288 (1981).

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. Craig B. Thompson and Paul E. Neiman: Department of Medicine, University of Washington, Seattle, Washington 98195, USA

  2. Mark Groudine: Department of Radiation Oncology, University of Washington, Seattle, Washington 98195, USA

Authors and Affiliations

  1. Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, Washington, 98104, USA

    Craig B. Thompson, Peter B. Challoner, Paul E. Neiman & Mark Groudine

Authors
  1. Craig B. Thompson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Peter B. Challoner
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Paul E. Neiman
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mark Groudine
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Thompson, C., Challoner, P., Neiman, P. et al. Expression of the c-myb proto-oncogene during cellular proliferation. Nature 319, 374–380 (1986). https://doi.org/10.1038/319374a0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/319374a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing