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Role of acetylcholine receptor subunits in gating of the channel

Nature volume 318, pages 538–543 (1985)Cite this article

Abstract

The Torpedo and calf acetylcholine receptors and hybrids composed of subunits from the two species have been produced in Xenopus oocytes by the use of the cloned complementary DNAs. Single-channel current measurements indicate that these receptors form channels of similar conductance but with different gating behaviour.

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Authors and Affiliations

  1. Max-Planck-Institut für biophysikalische Chemie, D-3400, Göttingen, FRG

    Bert Sakmann, Christoph Methfessel & Tomoyuki Takahashi

  2. Departments of Medical Chemistry and Molecular Genetics and *Physiology, Kyoto University Faculty of Medicine, Kyoto, 606, Japan

    Masayoshi Mishina, Tomoyuki Takahashi, Toshiyuki Takai, Masaaki Kurasaki, Kazuhiko Fukuda & Shosaku Numa

Authors
  1. Bert Sakmann
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  2. Christoph Methfessel
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  3. Masayoshi Mishina
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  4. Tomoyuki Takahashi
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  5. Toshiyuki Takai
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Sakmann, B., Methfessel, C., Mishina, M. et al. Role of acetylcholine receptor subunits in gating of the channel. Nature 318, 538–543 (1985). https://doi.org/10.1038/318538a0

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