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A molecular solution to the riddle of the giant panda's phylogeny

Nature volume 317, pages 140–144 (1985)Cite this article

Abstract

Although it is generally agreed that the giant panda (Ailuropoda melanoleuca) is a member of the order Carn­vora, there has long been disagreement over whether it should be classified with bears, raccoons or as a single member of its own family. Four independent molecular and genetic measures lead to a consensus phylogeny for the giant and lesser pandas. The lesser panda diverged from New World procyonids at approximately the same time as their departure from ursids, while ancestors of the giant panda split from the ursid lineage much later, just before the radiation which led to modern bears. The giant panda's divergence was accompanied by a chromosomal reorganization which can be partially reconstructed from the ursid karyotype, but not from that of procyonids or the lesser panda. The apparently dramatic, but actually limited, distinctions between the giant panda and the bears in chromosomal and anatomical morphology provide a graphic mammalian example of the discordance of molecular and morphological (and chromosomal) evolutionary change.

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References

  1. David, A. Nouv. Archs Mus. Hist. nat., Paris 5, 12–18 (1869).

    Google Scholar 

  2. Milne-Edwards, A. Ann. Sci. natn. Zool. Ser. 5 art 10, 1; C.r. hebd. Séanc. Acad. Sci., Paris 70, 341–342 (1870).

    Google Scholar 

  3. Davis, D. Fieldiana, Zool. Mem. 3 (Chicago Nat. Hist. Museum, 1964).

  4. Morris, D. & Morris, R. in The Giant Panda, 160–169 (Penguin, New York, 1981).

    Google Scholar 

  5. Thenius, V. E. Z. Säugetierk. Mitt. 44, 286–305 (1979).

    Google Scholar 

  6. Gould, S. J. in The Panda's Thumb, 19–34 (Norton, New York, 1980).

    Google Scholar 

  7. Peters, G. Z. Säugetierk. Mitt. 47, 236–246 (1982).

    Google Scholar 

  8. Kleiman, D. G. Z. Tierpsychol. 62, 1–46 (1983).

    Article  Google Scholar 

  9. Mivart St, G. Proc. zool Soc. Lond. 1885, 340–404 (1885).

    Google Scholar 

  10. Leone, C. A. & Wiens, A. L. J. Mammal. 37, 11–23 (1956).

    Article  Google Scholar 

  11. Sarich, V. Nature 245, 218–220 (1973).

    Article  ADS  Google Scholar 

  12. Ewer, R. The Carnivores (Cornell University Press, Ithaca, 1973).

    Google Scholar 

  13. Collins, L. R. & Page, J. K. Ling-Ling and Hsing-Hsing, Year of the Panda (Anchor Press/Doubleday, Garden City, 1973).

    Google Scholar 

  14. Gribbin, J. & Cherfas, J. The Monkey Puzzle; Reshaping the Evolutionary Tree (Pantheon, New York, 1982).

    Google Scholar 

  15. Wang, T. K. Acta zool. sin. 20, 191–201 (1974).

    Google Scholar 

  16. Chu, C. Acta zool. sin. 20, 174–187 (1974).

    Google Scholar 

  17. Pei, W.-C. Acta zool. sin. 20, 188–190 (1974).

    Google Scholar 

  18. Newnhan, R. & Davidson, M. Cytogenetics 5, 152–163 (1966).

    Article  Google Scholar 

  19. Wurster-Hill, D. & Bush, M. Cytogenet. Cell Genet. 27, 147–154 (1980).

    Article  CAS  PubMed  Google Scholar 

  20. Zuckerkandl, E. & Pauling, L. in Horizons in Biochemistry (eds Kasha, M. & Pullman, B.) 189–225 (Academic, New York, 1962).

    Google Scholar 

  21. Wilson, A. C., Carlson, S. S. & White, T. J. A. Rev. Biochem. 46, 573–639 (1977).

    Article  CAS  Google Scholar 

  22. Thorpe, J. P. A. Rev. Ecol. Syst. 13, 139–168 (1982).

    Article  CAS  Google Scholar 

  23. King, M. C. & Wilson, A. C. Science 188, 107 (1975).

    Article  ADS  CAS  PubMed  Google Scholar 

  24. Kohne, D. E., Chiscon, J. A. & Hoyer, B. H. J. hum. Evol. 1, 627–644 (1972).

    Article  Google Scholar 

  25. Bruce, E. J. & Ayala, F. J. Nature 276, 264–265 (1978).

    Article  ADS  CAS  PubMed  Google Scholar 

  26. Ferris, S. D., Wilson, A. C. & Brown, W. M. Proc. natn. Acad. Sci. U.S.A. 78, 2432–2436 (1981).

    Article  ADS  CAS  Google Scholar 

  27. Brown, W. M., Prager, E. M., Wang, A. & Wilson, A. C. J. molec. Evol. 18, 225–239 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  28. Sibley, C. G. & Ahlquist, J. E. J. molec. Evol. 20, 12–15 (1984).

    Article  ADS  Google Scholar 

  29. Benveniste, R. E. & Todaro, G. J. Nature 261, 101–108 (1976).

    Article  ADS  CAS  PubMed  Google Scholar 

  30. Britten, R. J. & Kohne, D. E. Science 161, 529–540 (1968).

    Article  ADS  CAS  PubMed  Google Scholar 

  31. Benveniste, R. in Molecular Evolutionary Genetics (ed. Maclntyre, R. J.) 359–417 (Plenum, New York, 1985).

    Book  Google Scholar 

  32. Brownell, E. Evolution 37, 1034–1051 (1983).

    Article  CAS  PubMed  Google Scholar 

  33. Farris, J. S. in Advances in Cladistics (eds Funk, V. A. & Brooks, D. R.) (New York Botanical Garden, 1982).

    Google Scholar 

  34. Felsenstein, J. Evolution 38, 16–24 (1984).

    Article  PubMed  Google Scholar 

  35. Farris, J. S. Cladistics 1, 51 (1985).

    Google Scholar 

  36. Sneath, P. H. A. & Sokal, R. R. in Numerical Taxonomy, 230–234 (Freeman, San Francisco, 1973).

    MATH  Google Scholar 

  37. Fitch, W. M. J. molec. Evol. 18, 30–37 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  38. Dayhoff, M. O. Atlas of Protein Sequence and Structure 1–8 (National Biomedical Research Foundation, Washington, DC, 1976).

  39. Fitch, W. M. & Margoliash, E. Science 155, 279–284 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  40. Sarich, V. & Wilson, A. C. Science 158, 1200–1204 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  41. Templeton, A. R. Evolution 37, 221–224 (1983).

    Article  CAS  PubMed  Google Scholar 

  42. Lewin, R. Science 226, 1179 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  43. Nei, M. Molecular Population Genetics and Evolution (North-Holland, Amsterdam, 1975).

    Google Scholar 

  44. Nowak, R. M. & Paradiso, J. L. Walker's Mammals of the World 4th edn (Johns Hopkins University Press, Baltimore, 1983).

    Google Scholar 

  45. Nei, M. Am. Nat. 106, 283–292 (1972).

    Article  Google Scholar 

  46. Nei, M. Genetics 89, 583–590 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  47. Avise, J. C. & Aquadro, C. F. in Evolutionary Biology (eds Hecht, M. K., Steere, W. C. & Wallace, B.) 151–185 (Plenum, New York, 1981).

    Google Scholar 

  48. Sarich, V. Syst. Zool. 18, 286–295 (1969).

    Article  CAS  PubMed  Google Scholar 

  49. Sarich, V. & Wilson, A. C. Proc. natn. Acad. Sci. U.S.A. 58, 142–148 (1967).

    Article  ADS  CAS  Google Scholar 

  50. Wurster-Hill, D. H. & Gray, C. W. Cytogenet. Cell Genet. 12, 377–397 (1973).

    Article  Google Scholar 

  51. Wurster-Hill, D. H. & Gray, C. W. Cytogenet. Cell Genet. 15, 306–331 (1975).

    Article  CAS  PubMed  Google Scholar 

  52. Wurster-Hill, D. H. & Centerwall, W. R. Cytogenet. Cell Genet. 34, 178–192 (1982).

    Article  CAS  PubMed  Google Scholar 

  53. Pilbeam, D. Nature 295, 232–234 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  54. Gould, S. J. & Eldredge, N. Paleobiology 3, 115–151 (1977).

    Article  Google Scholar 

  55. Stanley, S. M. Proc. natn. Acad. Sci. U.S.A. 72, 646–650 (1975).

    Article  ADS  CAS  Google Scholar 

  56. Stanley, S. (ed.) Macroevolution: Patterns and Processes (Freeman, San Francisco, 1979).

  57. Wilson, A. C., Bush, G. L., Case, S. M. & King, M. C. Proc. natn. Acad. Sci. U.S.A. 12, 5061–5065 (1975).

    Article  ADS  Google Scholar 

  58. Bush, G. L., Case, S. M., Wilson, A. C. & Patton, J. L. Proc. natn. Acad. Sci. U.S.A. 74, 3942–3946 (1977).

    Article  ADS  CAS  Google Scholar 

  59. O'Brien, S. J., Seuanez, H. N. & Womack, J. E. in Molecular Evolutionary Genetics (ed. MacIntyre, R. J.) 519–589 (Plenum, New York, 1985).

    Book  Google Scholar 

  60. Champion, A. B., Prager, E. M., Wachter, D. & Wilson, A. C. in Biochemical and Immunological Taxonomy of Animals (ed. Wright, C. A.) 397–416 (Academic, New York, 1974).

    Google Scholar 

  61. Leakey, R. E. & Lewin, R. Origins, the Emergence and Evolution of Our Species and Its Possible Future (Dutton, New York, 1982).

    Google Scholar 

  62. O'Brien, S. J. & Nash, W. G. Science 216, 257–265 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  63. Shows, T. & McAlpine, P. Cytogenet. Cell Genet. 37, 340–393 (1984).

    Article  CAS  PubMed  Google Scholar 

  64. Nash, W. G. & O'Brien, S. J. Proc. natn. Acad. Sci. U.S.A. 79, 6631–6635 (1982).

    Article  ADS  CAS  Google Scholar 

  65. Harris, H. & Hopkinson, D. A. Handbook of Enzyme Electrophoresis in Human Genetics (North-Holland, Amsterdam, 1976).

    Google Scholar 

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Authors and Affiliations

  1. Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, Maryland, 21701, USA

    Stephen J. O'Brien, William G. Nash, David E. Wildt & Raoul E. Benveniste

  2. Department of Animal Health, National Zoological Park, Smithsonian Institution, Washington, DC, 20008, USA

    Stephen J. O'Brien, David E. Wildt & Mitchell E. Bush

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  1. Stephen J. O'Brien
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  4. Mitchell E. Bush
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  5. Raoul E. Benveniste
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O'Brien, S., Nash, W., Wildt, D. et al. A molecular solution to the riddle of the giant panda's phylogeny. Nature 317, 140–144 (1985). https://doi.org/10.1038/317140a0

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